572630
SU-5402
≥95% (HPLC), lyophilized solid, FGFR1 inhibitor, Calbiochem
別名:
SU5402, 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
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この商品について
実験式（ヒル表記法）:
C17H16N2O3
CAS番号:
分子量:
296.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
製品名
SU5402, SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC50 = 10-20 µM in the presence of 1 mM ATP).
SMILES string
[nH]1c(c(c(c1)C)CCC(=O)O)\C=C2\c3c(cccc3)NC\2=O
InChI
1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
InChI key
JNDVEAXZWJIOKB-JYRVWZFOSA-N
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
solubility
DMSO: 25 mg/mL
shipped in
ambient
Quality Level
storage temp.
2-8°C
Biochem/physiol Actions
Primary Target
Fibroblast growth factor receptor 1 (FGFR1)
Fibroblast growth factor receptor 1 (FGFR1)
Product competes with ATP.
Reversible: yes
Cell permeable: yes
Target IC50: 10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.
Legal Information
Not available for sale in the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Mohammadi, M., et al. 1997. Science 276, 955.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
H J Standley et al.
Development (Cambridge, England), 128(8), 1347-1357 (2001-03-23)
The community effect is an interaction among a group of many nearby precursor cells, necessary for them to maintain tissue-specific gene expression and differentiate co-ordinately. During Xenopus myogenesis, the muscle precursor cells must be in group contact throughout gastrulation in
Julia Leschik et al.
Nature protocols, 3(9), 1381-1387 (2008-09-06)
Primate nonhuman and human embryonic stem (ES) cells provide a powerful model of early cardiogenesis. Furthermore, engineering of cardiac progenitors or cardiomyocytes from ES cells offers a tool for drug screening in toxicology or to search for molecules to improve
Federico Tessadori et al.
eLife, 10 (2021-08-11)
Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established during embryogenesis. The heart is the first organ to display visible left-right asymmetries through its left-sided positioning and rightward looping. Here, we present
Gabsang Lee et al.
Nature protocols, 5(4), 688-701 (2010-04-03)
Human pluripotent stem cell (hPSC)-derived neural crest (NC) cells present a valuable tool for modeling aspects of human NC development, including cell fate specification, multipotency and cell migration. hPSC-derived NC cells are also suitable for modeling human disease and as
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| 572630-2MGCN | 04055977266238 |
| 572630-500UGCN | 04055977266269 |
| 572630-1MGCN | 04055977266207 |
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