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681671

IWP-2

Name: IWP-2
Brand: MM

≥97% (HPLC), solid, Wnt antagonist, Calbiochem

別名:

Wnt Antagonist II, IWP-2, Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

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この商品について

実験式（ヒル表記法）:

C₂₂H₁₈N₄O₂S₃

CAS番号:

686770-61-6

分子量:

466.60

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD04457599

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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特性

製品名

Wnt Antagonist II, IWP-2, The Wnt Antagonist II, IWP-2, also referenced under CAS 686770-61-6, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

off-white

solubility

DMSO: 2.5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[s]1c2c(nc1NC(=O)CSc3[n]([c](c5c(n3)CCS5)=O)c4ccccc4)ccc(c2)C

InChI

1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)

InChI key

WRKPZSMRWPJJDH-UHFFFAOYSA-N

詳細

General description

A cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chen, B., et al. 2009. Nature Chem. Biol.5, 100.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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保管分類

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c