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Merck

AB5977

Anti-Musashi-1 Antibody

Chemicon®, from rabbit

別名:

Musashi homolog 1

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC, WB
Citations:
66

主要文書

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rodent, mouse, rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NM_002442.2

UniProt accession no.

O43347

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MSI1(4440)

General description

39 kDa
In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, differentiation and tumorigenesis. Musashi1 (also known as Msi1), is selectivley expressed in neural progenitor cells, including neural stem cells. Outside the nervous system, Musashi1 is a selective marker for intestinal stem or early lineage cells. Musashi1 interacts with the Notch pathway during asymmetric cell division by binding the 3′ UTR of Numb. Numb is prevented from repressing Notch signaling when Musashi1 is present.

Immunogen

Synthetic peptide, amino acids 5-21 of Musashi.

Application

Detect Musashi-1 using this Anti-Musashi-1 Antibody validated for use in IC, IH & WB.
Immunohistochemistry:
1:200-1:1,000 dilution from a previous lot was used.

Immunocytochemistry:
1:200-1:1,000 dilution from a previous lot was used.

Western blot:
1:200-1:1,000 using ECL.

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Developmental Neuroscience

RNA Binding Protein (RBP)

Biochem/physiol Actions

Reactivity with other species has not been confirmed.
Recognizes Musashi-1.

Physical form

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.

Preparation Note

Stable for 1 year at -80ºC from date of receipt.

Analysis Note

Control
Mouse cortical neural stem cells (Catalog No. SCR029).
Routinely evaluated by Western Blot on Human Placenta lysates.

Western Blot Analysis:
1:1000 dilution of this lot detected Musashi-1 on 10 μg of Human placenta lysates.

Other Notes

Replaces: 03-114; 04-1041

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

AB5977:

jan

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions
Shin, Soojung, et al.
Stem Cells, 24, 125-138 (2006)
Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration.
Gonzalez, LM; Williamson, I; Piedrahita, JA; Blikslager, AT; Magness, ST
Testing null
Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice
Maslov, Alexander Y, et al.
The Journal of Neuroscience, 24, 1726-1733 (2004)
Postnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasia.
Adrian G Cummins, Ben J Jones, Fiona M Thompson
Digestive Diseases and Sciences null
Raffaella Scardigli et al.
Stem cells (Dayton, Ohio), 32(9), 2516-2528 (2014-05-09)
Adult neurogenesis is a multistep process regulated by several extrinsic factors, including neurotrophins. Among them, little is known about the role of nerve growth factor (NGF) in the neurogenic niches of the mouse. Here we analyzed the biology of adult
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関連コンテンツ

RNA-Binding Protein Immunoprecipitation

All eukaryotic organisms require tight regulation of gene expression for complex processes such as development, differentiation, cell specification, and responses to environmental stimuli. Many genes are regulated post-transcriptionally, in addition to transcriptional mechanisms of gene regulation. RNA-binding proteins (RBPs) are essential for post-transcriptional gene regulation, linking transcription and translation in many processes including transcription, splicing, export, rate of translation and turnover. In all of these events, RBPs coordinate regulation of the amount of protein produced from mRNA transcripts.

グローバルトレードアイテム番号

カタログ番号GTIN
AB597704053252474750

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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