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Merck

ABN1385

Anti-RanBP2 Antibody

from rabbit, purified by affinity chromatography

別名:

E3 SUMO-protein ligase RanBP2, 358 kDa nucleoporin, Nuclear pore complex protein Nup358, Nucleoporin Nup358, Ran-binding protein 2, RanBP2, p270, ADANE, ANE1, IIAE3, Transformation-Related Protein 2, TRP1, TRP2

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この商品について

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, mouse
Application:
IF, IHC
Citations:
5

主要文書

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biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable

NCBI accession no.

NP_006258

UniProt accession no.

P49792

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... RANBP2(5903)

General description

358.2 kDa calculated
RAN-binding protein 2 (RanBP2), also known as Nucleoporin Nup358 (Nup358), is encoded by the RANBP2 gene. RanBP2/Nup358 regulates functions of multiple cellular proteins through direct interactions via distinct domains. RanBP2/Nup358 binding partners include Ran GTPase, importin-beta, exportin-1/CRM1, red opsin, subunits of the proteasome, cox11, the kinesin-1 isoforms KIF5B and KIF5C, and E2 enzyme UBC9, where it functions as an E3 SUMO-protein ligase and facilitates subsequent SUMOylation of protein substrates such as RanGAP and SP100.

Immunogen

Epitope: Internal repeat IR1+2 domain (IR)
Recombinant protein corresponding to the internal repeat IR1+2 domain (IR) of human RanBP2.

Application

Anti-RanBP2 Antibody is an antibody against RanBP2 Antibody for use in Immunohistochemistry, Immunofluorescence.
Immunofluorescence Analysis: A 1:50 dilution from a representative lot detected RanBP2 in mouse retina cells (Paulo Ferreira, Duke University)
Immunofluorescence Analysis: A representative lot detected in mouse retina of RanBP2 transgenic mice (Cho, K., et al. (2014). JBC. 1-31).
Research Category
Neuroscience
Research Sub Category
Developmental Signaling

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Immunohistochemistry in human retina tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected RanBP2 in human retina tissue.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類

10 - Combustible liquids

wgk

WGK 2

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

ABN1385:

jan

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Jeeyoung Lee et al.
Cells, 10(9) (2021-09-29)
Cellular stress induces the formation of membraneless protein condensates in both the nucleus and cytoplasm. The nucleocytoplasmic transport of proteins mainly occurs through nuclear pore complexes (NPCs), whose efficiency is affected by various stress conditions. Here, we report that hyperosmotic
Kyoung-in Cho et al.
The Journal of biological chemistry, 289(8), 4600-4625 (2014-01-10)
The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomerization (PPIase), a rate-limiting step in protein folding and a conformational switch in protein function. Cyclophilins are also chaperones. Noncatalytic mutations affecting the only cyclophilins with known but distinct physiological substrates, the Drosophila NinaA
Samuel S Pappas et al.
Human molecular genetics, 27(3), 407-420 (2017-12-01)
A critical challenge to deciphering the pathophysiology of neurodevelopmental disease is identifying which of the myriad abnormalities that emerge during CNS maturation persist to contribute to long-term brain dysfunction. Childhood-onset dystonia caused by a loss-of-function mutation in the AAA+ protein torsinA
Baojin Ding et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(9), 2024-2038 (2021-01-21)
DYT1 dystonia is a hereditary neurologic movement disorder characterized by uncontrollable muscle contractions. It is caused by a heterozygous mutation in Torsin A (TOR1A), a gene encoding a membrane-embedded ATPase. While animal models provide insights into disease mechanisms, significant species-dependent

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