MILLIPLEX^® Human Cytokine/Chemokine Panel 3

Cytokines are versatile signaling molecules that regulate immune cell communication, inflammation, and tissue homeostasis. In metabolic and autoimmune disorders, dysregulated cytokine networks drive chronic inflammation, insulin resistance, and tissue damage. Chemokines, a subset of cytokines, direct immune cell migration to sites of injury or infection, while growth factors like M-CSF modulate cell proliferation and repair. In obesity, pro-inflammatory cytokines exacerbate adipose tissue dysfunction, whereas in autoimmune diseases, they promote aberrant immune activation against self-tissues. Conversely, anti-inflammatory cytokines work to restore equilibrium, highlighting their dual role as both drivers of pathology and potential therapeutic targets. Understanding these dynamic interactions is key to developing interventions for conditions ranging from IBD to metabolic syndrome.

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 11 analytes in human serum, plasma, and cell culture supernatants.Analytes included: GCP2, HCC-1, I-TAC, IL-11, IL-29, Lymphotactin, M-CSF, MIG, MIP-3α, MIP-3β, NAP2Note: HCC-1/CCL14a and NAP-2/CXCL7 cannot be plexed with other analytes for serum/plasma.Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Targeted Multiplex Profiling: Simultaneously quantify 11 cytokines/chemokines (e.g., MIP-3α, IL-29, M-CSF) linked to metabolic disorders, obesity, and autoimmune mechanisms, enabling focused study of immune-inflammatory pathways.Luminex^® xMAP^® Technology: Magnetic bead-based multiplexing ensures high sensitivity and throughput with minimal sample volume (serum, plasma, or culture supernatants).Configure Your Panel: Select specific analytes (e.g., I-TAC, Lymphotactin) to tailor assays to your research needs, reducing costs and optimizing efficiency.Optimized Sample Dilutions: Run most analytes neat (except NAP-2 and HCC-1, requiring 1:100 dilution for serum/plasma), simplifying workflow for diverse sample types.Accelerate Translational Insights: Investigate chemokine networks in metabolic syndrome or autoimmune diseases and uncover therapeutic targets (e.g., IL-29 in viral responses, M-CSF in macrophage activation).

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.