MABE282
Anti-c-Myc Tag Antibody
mouse monoclonal, 9E10
別名:
Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, HLHe39, Proto-oncogene c-Myc, Transcription factor p64
製品名
Anti-c-Myc Antibody, clone 9E10, clone 9E10, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
9E10, monoclonal
species reactivity
human
technique(s)
ChIP: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYC(4609)
Analysis Note
Control
HeLa cell lysate
HeLa cell lysate
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected c-Myc in 10 µg of HeLa cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected c-Myc in 10 µg of HeLa cell lysate.
Application
Anti-c-Myc Antibody, clone 9E10 is a Mouse Monoclonal Antibody for detection of c-Myc also known as Myc proto-oncogene protein, HLHe39, Transcription factor p64 & has been validated in WB, ChIP.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Cell Cycle, DNA Replication & Repair
Western Blot Analysis: A representative lot from an independent laboratory detected c-Myc in various cell lysates (Evan, G. I., et al. (1985). Mol Cell Biol. 5(12):3610-3616).
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected c-Myc in ChIP (Sanyal, K., et al. (2004). Proc Natl Acad Sci USA. 101(31):11374-11379).
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory detected c-Myc in ChIP (Sanyal, K., et al. (2004). Proc Natl Acad Sci USA. 101(31):11374-11379).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
c-Myc (bHLHe39) is a transcription factor that regulates the expression of multiple genes involved in apoptosis, cell differentiation and cell proliferation. Active c-Myc is coupled to the MAX protein via c-Myc’s C-terminal helix-loop-helix leucine zipper (bHLHLZ) domain. The c-Myc-MAX heterodimer also interacts with a number of other transcription-related proteins including TRRAP, p107 and Miz-1, and c-Myc-MAX may indirectly regulate histone acetylases involved in chromatin remodeling to increase accessibility of transcriptional complexes to target DNA sequences. The expression of c-Myc is controlled by growth factors. Several studies have reported abnormal expression of c-Myc in various cancers including Burkitt’s lymphoma.
~51 kDa observed. Uniprot describes two isoforms at ~49 kDa and ~51 kDa
Immunogen
Linear peptide corresponding to human c-Myc.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Samuel Rommelaere et al.
Cell reports, 27(3), 886-899 (2019-04-18)
In ectotherms, increased ambient temperature requires the organism to consume substantial amounts of energy to sustain a higher metabolic rate, prevent cellular damage, and respond to heat stress. Here, we identify a heat-inducible apolipoprotein required for thermal acclimation in Drosophila.
Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique.
Sanyal, Kaustuv, et al.
Proceedings of the National Academy of Sciences of the USA, 101, 11374-11379 (2004)
Justina Rutkauskaite et al.
iScience, 25(7), 104515-104515 (2022-06-24)
High-throughput screening and enrichment of antibody-producing cells have many important applications. Herein, we present a droplet microfluidic approach for high-throughput screening and sorting of antibody-secreting cells using a Förster resonance electron transfer (FRET)-based assay. The FRET signal is mediated by
David Z Kochan et al.
Journal of cell science, 134(15) (2021-08-06)
Gene expression involves regulation of chromatin structure and transcription, as well as processing of the transcribed mRNA. While there are feedback mechanisms, it is not clear whether these include crosstalk between chromatin architecture and mRNA decay. To address this, we
Yang Sun et al.
Nature communications, 13(1), 6744-6744 (2022-11-09)
Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and analogues block cancer cell "stemness", organ overgrowth and tumor initiation in vitro and in vivo. MGH-CP1 sensitivity correlates
関連コンテンツ
New Products: Antibodies, Assays, Small Molecules, Inhibitors, and Proteins
グローバルトレードアイテム番号
| カタログ番号 | GTIN |
|---|---|
| MABE282 | 04053252549298 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）