03738
5-フルオロウラシル
analytical standard
別名:
2,4-ジヒドロキシ-5-フルオロピリミジン, 5-FU, 5-フルオロ-2,4(1H,3H)-ピリミジンジオン
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この商品について
実験式（ヒル表記法）:
C4H3FN2O2
CAS番号:
分子量:
130.08
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-085-6
Beilstein/REAXYS Number:
127172
MDL number:
製品名
5-フルオロウラシル, analytical standard
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
SMILES string
FC1=CNC(=O)NC1=O
grade
analytical standard
assay
≥99.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤0.5% water
mp
282-286 °C (dec.) (lit.)
application(s)
cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)
format
neat
Quality Level
Gene Information
human ... TYMS(7298)
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Application
5-Fluorouracil may be used as an analytical standard for the determination of the analyte in hospital effluents by capillary electrophoresis, and in biological samples and environmental samples by chromatography based techniques.
General description
5-Fluorouracil is an anti-tumor agent, widely used in the treatment of various malignancies.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
5-fluorouracil: mechanisms of action and clinical strategies
Longley DB, et al.
Nature Reviews. Cancer, 3(5), 330-338 (2003)
G Micoli et al.
Journal of chromatography. B, Biomedical sciences and applications, 750(1), 25-32 (2001-02-24)
5-Fluorouracil (5-FU) is one of the most widely used antineoplastic drugs. It can be therefore considered to be a model compound for the identification of exposure routes during preparation and administration of cytostatic agents, especially for nucleoside analogue drugs. In
André Bp van Kuilenburg et al.
Pharmacogenomics, 14(7), 799-811 (2013-05-09)
5-fluorouracil (5-FU) remains the cornerstone of all currently applied regimens for the treatment of patients with cancers of the gastrointestinal tract, breast, and head and neck. Unfortunately, a large variation in the clearance of 5-FU has been observed between patients
Larissa S Carnevalli et al.
The Journal of experimental medicine, 211(5), 769-779 (2014-04-23)
The serine protease granzyme B (GzmB) is stored in the granules of cytotoxic T and NK cells and facilitates immune-mediated destruction of virus-infected cells. In this study, we use genetic tools to report novel roles for GzmB as an important
Tania Diaz et al.
Journal of surgical oncology, 109(7), 676-683 (2014-02-11)
Surgery is the standard treatment for colorectal cancer (CRC), and adjuvant chemotherapy has been shown to be effective in stage III but less so in stage II. We have analyzed the expression of the miR-200 family in tissue samples from
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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