59964
ヒスタミン
analytical standard
別名:
2-(4-イミダゾリル)エチルアミン
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この商品について
実験式（ヒル表記法）:
C5H9N3
CAS番号:
分子量:
111.15
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-100-6
Beilstein/REAXYS Number:
2012
MDL number:
製品名
ヒスタミン, analytical standard
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
SMILES string
NCCc1c[nH]cn1
grade
analytical standard
assay
≥97.0% (TLC)
≥97.0% (anhydrous basis, NT)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤4.0% water
color
white to light yellow
bp
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
format
neat
storage temp.
−20°C
Quality Level
Gene Information
human ... HRH1(3269)
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関連するカテゴリー
Application
適切な装置技術に関するさらなる情報については製品の分析試験証明書をご参照ください。さらなるサポートについてはTechnical Serviceまでお問い合わせください。
Biochem/physiol Actions
内在性のヒスタミン受容体H1 , H2 のアゴニストです。H1 の活性化によりCa2+が動員されます。H2の活性化により神経細胞のアデニル酸シクラ-ゼの活性が刺激されます。一酸化窒素シンタ-ゼを活性化します。強力な血管拡張剤です。
内在性のヒスタミン受容体H1および H2のアゴニストです。一酸化窒素シンテタ-ゼを活性化します。強力な血管拡張剤です。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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We estimate and compare change in iris cross-sectional area (IA) after physiologic and pharmacologic mydriasis in subjects with different dominant mechanisms for primary angle closure. Anterior segment optical coherence tomography (AS-OCT) measurements in light, dark, and following pharmacologic dilation were
Mohamed H Shamji et al.
The Journal of allergy and clinical immunology, 135(4), 913-921 (2014-12-03)
Immunotherapy inhibits basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immunotherapy withdrawal. Intracellular fluorochrome-labeled diamine oxidase (DAO) was used as a novel functional readout of basophil histamine release after immunotherapy. Results were
P J Turner et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 25(7), 657-661 (2014-10-10)
Most children with egg allergy tolerate egg in baked foods, such as cake, but tolerance cannot be predicted with conventional allergy testing. We hypothesized that the skin prick test (SPT) wheal to unprocessed raw egg might predict tolerance of baked
Andrea Strasser et al.
Trends in pharmacological sciences, 34(1), 13-32 (2012-12-12)
Histamine is a biogenic amine that exerts its biological effects as a neurotransmitter and local mediator via four histamine receptor (HR) subtypes (H(x)Rs) - H(1)R, H(2)R, H(3)R, and H(4)R - belonging to the superfamily of G-protein-coupled receptors (GPCRs). All four
Ruth Ferstl et al.
Frontiers in bioscience (Landmark edition), 17, 40-53 (2011-12-29)
Histamine influences many cell types involved in the regulation of innate and adaptive immune responses including antigen-presenting cells (APCs), Natural Killer (NK) cells, epithelial cells, T lymphocytes and B lymphocytes. These cells express histamine receptors (HRs) and also secrete histamine
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