N-ラウロイルサルコシン

Name: <I>N</I>-ラウロイルサルコシン
Brand: SIAL

≥98.0% (GC), suitable for protein quantification, purum p.a.

別名:

N-ドデカノイル-N-メチルグリシン, サルコシルL

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この商品について

化学式:

CH₃(CH₂)₁₀CON(CH₃)CH₂COOH

CAS番号:

97-78-9

分子量:

271.40

NACRES:

NA.21

PubChem Substance ID:

57651861

UNSPSC Code:

12352100

EC Number:

202-608-3

MDL number:

MFCD00021749

Beilstein/REAXYS Number:

1792084

主要文書

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製品名

N-ラウロイルサルコシン, purum p.a., ≥98.0% (GC)

InChI key

BACYUWVYYTXETD-UHFFFAOYSA-N

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

SMILES string

CCCCCCCCCCCC(=O)N(C)CC(O)=O

description

anionic

grade

purum p.a.

assay

≥98.0% (GC)

mol wt

271.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.2% water

ign. residue

≤0.1%

mp

45-50 °C

anion traces

chloride (Cl^-): ≤50 mg/kg
sulfate (SO₄^2-): ≤100 mg/kg

cation traces

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤70 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤20 mg/kg

functional group

amide
carboxylic acid

Quality Level

200

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Application

N-Lauroylsarcosine may be used as a permeation enhancer in the transdermal drug delivery formulations since it increases the fluidity of stratum corneum lipid structure of the skin†

General description

N-Lauroylsarcosine (N-Dodecanoyl-N-methylglycine, Sarkosyl L, LS) is an anionic surfactant. Its microbicidal action against herpes simplex type 2 (HSV-2) intravaginal infection in a murine model has been investigated.

pictograms

GHS06,GHS05

signalword

Danger

hcodes

H315,H318,H330

pcodes

P260 - P264 - P280 - P302 + P352 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

保管分類

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol.

Yeu-Chun Kim et al.

International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)

To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery

Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model.

Kunie Ando et al.

The American journal of pathology, 178(2), 803-816 (2011-02-02)

Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mutant tau, we generated a

A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions.

Yoshiaki Furukawa et al.

The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)

The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here

Thermoreversible gel formulations containing sodium lauryl sulfate or n-Lauroylsarcosine as potential topical microbicides against sexually transmitted diseases.

S Roy et al.

Antimicrobial agents and chemotherapy, 45(6), 1671-1681 (2001-05-17)

The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.

Jian Sun et al.

Nucleic acids research, 43(14), 6827-6846 (2015-07-04)

The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation

N-ラウロイルサルコシン

≥98.0% (GC), suitable for protein quantification, purum p.a.

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この商品について

主要文書

特性

製品名

InChI key

InChI

SMILES string

description

grade

assay

mol wt

technique(s)

impurities

ign. residue

mp

anion traces

cation traces

functional group

Quality Level

関連するカテゴリー

詳細

Application

General description

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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