63176
6-マレイミドヘキサン酸
≥98.0% (HPLC)
別名:
6-マレイミドカプロン酸, N-マレオイル-6-アミノカプロン酸, N-(5-カルボキシペンチル)マレイミド
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この商品について
実験式（ヒル表記法）:
C10H13NO4
CAS番号:
分子量:
211.21
UNSPSC Code:
12352005
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1532405
Application
6-マレイミドヘキサン酸は、医薬品およびその他のタイプの生体接合体の構築の際のスペーサーとして使用することができます。6-マレイミドヘキサン酸は二官能性架橋試薬としてN- ヒドロキシコハク酸イミドエステルとの併用で使用されます。
膜タンパク中のチオール基（SH基）を探査します。
signalword
Warning
hcodes
Hazard Classifications
Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Mitsuko Maeda et al.
Bioorganic & medicinal chemistry letters, 15(3), 621-624 (2005-01-25)
The adenovirus vector is a promising carrier for the efficient transfer of genes into cells via the coxackie-adenovirus receptor (CAR) and integrins (alphavbeta3 and alphavbeta5). The clinical use of the adenovirus vector remains problematic however. Successful administration of this vector
Shinya Kida et al.
Chemical & pharmaceutical bulletin, 55(4), 685-687 (2007-04-06)
6-maleimidohexanoic acid N-hydroxysuccinimide ester has been used widely for preparation of enzyme immunoconjugates as a unique heterobifunctional cross-linking reagent. Its heterobifunctional reactivity is good, but its ester portion hydrolyzes easily in the presence of water. Several 6-maleimidohexanoic acid active esters
Ralph Rahme et al.
Journal of neurosurgery, 121(6), 1354-1358 (2014-09-27)
The role of endovascular therapy in patients with acute ischemic stroke and a solitary M2 occlusion remains unclear. Through a pooled analysis of 3 interventional stroke trials, the authors sought to analyze the impact of successful early reperfusion of M2
Mohammed Abdelsaid et al.
Life sciences, 118(2), 268-273 (2014-01-23)
We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1
S S Ghosh et al.
Bioconjugate chemistry, 1(1), 71-76 (1990-01-01)
Two general methods which exploit the reactivity of sulfhydryl groups toward maleimides are described for the synthesis of oligonucleotide-enzyme conjugates for use as nonradioisotopic hybridization probes. In the first approach, 6-maleimidohexanoic acid succinimido ester was used to couple 5'-thiolated oligonucleotide
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