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76899

テモゾロミド

VETRANAL®, analytical standard

別名:

3,4-ジヒドロ-3-メチル-4-オキソイミダゾ[5,1-d]-1,2,3,5-テトラジン-8-カルボキサミド, 3-メチル-4-オキソ-8-イミダゾロ[5,1-d][1,2,3,5]テトラジンカルボキサミド, 4-メチル-5-オキソ-2,3,4,6,8-ペンタアザビシクロ[4.3.0]ノナ-2,7,9-トリエン-9-カルボキサミド, 8-カルバモイル-3-メチルイミダゾ[5,1-d]-1,2,3,5-テトラジン-4(3H)-オン, NSC 362856

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この商品について

実験式（ヒル表記法）:
C6H6N6O2
CAS番号:
85622-93-1
分子量:
194.15
NACRES:
NA.24
PubChem Substance ID:
329767423
UNSPSC Code:
41116107
MDL number:
MFCD00866492
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grade

analytical standard

Quality Level

100

product line

VETRANAL®

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

ign. residue

≤0.2%

loss

≤0.5% loss on drying

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CN1N=Nc2c(ncn2C1=O)C(N)=O

InChI

1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

InChI key

BPEGJWRSRHCHSN-UHFFFAOYSA-N

General description

Temozolomide (TMZ) is an alkylating agent of the imidazotetrazine derivatives that shows broad-spectrum antitumor activity against murine tumors.

Application

TMZ may be used as a reference standard for the analysis of temozolomide in serum and brain tumor samples by micellar electrokinetic capillary chromatography (MEKC), in aqueous solutions by liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS/MS), in active pharmaceutical ingredients (APIs) by high performance liquid chromatography (HPLC) with MS/MS and in pharmaceutical dosage form by HPLC equipped with photodiode array (PDA) detector.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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試験成績書（COA）

Lot/Batch Number

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Multianalyte determination of 24 cytostatics and metabolites by liquid chromatography-electrospray-tandem mass spectrometry and study of their stability and optimum storage conditions in aqueous solution.
Negreira N, et al.
Talanta, 116(23), 290-299 (2013)
Development and Validation of Simultaneous Detrmination of Anastrozole and Temozolomide in Pharmaceutical Dosage Forms.
Daphal VN, et al.
International Journal of Theoretical & Applied Sciences, 4(23), 48-55 (2012)
Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.
Andrasi M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879(23), 2229-2233 (2011)
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