A5000
アセトアミノフェン
meets USP testing specifications, 98.0-102.0%, powder
別名:
4′-ヒドロキシアセトアニリド, 4-アセトアミドフェノール, N-(4-ヒドロキシフェニル)アセトアミド, N-アセチル-4-アミノフェノール, APAP, パラセタモール
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この商品について
化学式:
CH3CONHC6H4OH
CAS番号:
分子量:
151.16
UNSPSC Code:
12352111
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2208089
製品名
アセトアミノフェン, meets USP testing specifications, 98.0-102.0%, powder
InChI
1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
SMILES string
CC(=O)Nc1ccc(O)cc1
InChI key
RZVAJINKPMORJF-UHFFFAOYSA-N
agency
USP/NF
meets USP testing specifications
assay
98.0-102.0%
form
powder
mp
168-172 °C (lit.)
solubility
DMSO: 5 M
ethanol: 50 mg/mL
H2O: very slightly soluble
application(s)
pharmaceutical (small molecule)
Quality Level
Gene Information
human ... FAAH(2166), PTGS1(5742), PTGS2(5743), TRPV1(7442)
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Application
鎮痛薬
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
364.3 °F - Pensky-Martens closed cup
flash_point_c
184.6 °C - Pensky-Martens closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Mohammad A Rahman et al.
Scientific reports, 9(1), 6571-6571 (2019-04-27)
Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytochrome P450
S M de Morais et al.
Gastroenterology, 102(2), 577-586 (1992-02-01)
Gilbert's syndrome occurs in 5%-7% of the human population and is caused by an inherited deficiency in the glucuronidation of endogenous bilirubin, resulting in its accumulation and jaundice. The authors of the present study have previously shown that rats with
Edward Munsterhjelm et al.
Anesthesiology, 103(4), 712-717 (2005-09-30)
Acetaminophen (paracetamol) is widely used for postoperative analgesia. Its mechanism of action is inhibition of prostaglandin synthesis in the central nervous system, and acetaminophen is traditionally not considered to influence platelet function. The authors studied the dose-dependent inhibition of platelet
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
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