H4784
ヘパリン ナトリウム塩 from porcine intestinal mucosa
≥180 USP units/mg
製品名
ヘパリン ナトリウム塩 from porcine intestinal mucosa, ≥180 USP units/mg
SMILES string
[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O
InChI key
JRTRSJGZMRQDHI-UHFFFAOYSA-N
biological source
Porcine intestinal mucosa
form
powder
specific activity
≥180 USP units/mg
solubility
H2O: 50 mg/mL, clear, colorless to faintly yellow
cation traces
Ca: ≤20 ppm
storage temp.
2-8°C
Quality Level
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Analysis Note
カルシウム低含有
General description
メルクのダウンストリームプロセス用化学物質の包括的なポートフォリオは、バイオ医薬品メーカーに従来・新規治療薬の製造のための高品質原材料を提供するだけでなく、上市時間を短縮して、規制関連課題を単純化できるようにサポートします。低リスクの用途向けの非GMPグレードから、高リスクの用途向けのIPEC-PQG GMPまで、お客様のあらゆる製造ニーズに対応する製品を取り揃えています。
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Linda Cruz et al.
PloS one, 8(7), e68379-e68379 (2013-07-19)
Human papillomavirus (HPV) infection is the leading cause of cervical cancer world-wide. Here, we show that native HPV particles produced in a differentiated epithelium have developed different strategies to infect the host. Using biochemical inhibition assays and glycosaminoglycan (GAG)-negative cells
Eve Draper et al.
PloS one, 8(5), e61825-e61825 (2013-05-08)
The current generation of Human Papillomavirus (HPV) vaccines, Cervarix® and Gardasil®, exhibit a high degree of efficacy in clinical trials against the two high-risk (HR) genotypes represented in the vaccines (HPV16 and HPV18). High levels of neutralizing antibodies are elicited
Felix J Hartmann et al.
Cell reports, 28(3), 819-831 (2019-07-18)
The success of immunotherapy has led to a myriad of clinical trials accompanied by efforts to gain mechanistic insight and identify predictive signatures for personalization. However, many immune monitoring technologies face investigator bias, missing unanticipated cellular responses in limited clinical
Sara L Bissett et al.
Scientific reports, 6, 39730-39730 (2016-12-23)
The human papillomavirus (HPV) vaccines consist of major capsid protein (L1) virus-like particles (VLP) and are highly efficacious against the development of cervical cancer precursors attributable to oncogenic genotypes, HPV16 and HPV18. A degree of vaccine-induced cross-protection has also been
William H Thiel et al.
PloS one, 7(9), e43836-e43836 (2012-09-11)
The broad applicability of RNA aptamers as cell-specific delivery tools for therapeutic reagents depends on the ability to identify aptamer sequences that selectively access the cytoplasm of distinct cell types. Towards this end, we have developed a novel approach that
資料
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
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