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この商品について
化学式:
(CH3)3N+CH2CH(OH)CH2COO-
CAS番号:
分子量:
161.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4292315
製品名
L-カルニチン 分子内塩, European Pharmacopoeia (EP) Reference Standard
SMILES string
C[N+](C)(C)C[C@H](O)CC([O-])=O
InChI key
PHIQHXFUZVPYII-ZCFIWIBFSA-N
InChI
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
grade
pharmaceutical primary standard
API family
levocarnitine
manufacturer/tradename
EDQM
mp
197-212 °C (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
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関連するカテゴリー
Biochem/physiol Actions
カルニチンは、多くの哺乳類組織に存在する四級アミンです。エネルギ-代謝調節に関与する骨格筋や心臓に比較的高濃度で存在します。糖代謝を解糖からグリコ-ゲン貯蔵へ変換し、ミトコンドリアへの長鎖脂肪酸の輸送を促進します。輸送された長鎖脂肪酸はミトコンドリアでエネルギ-産生のために酸化されます。
General description
この製品は薬局方標準品です。発行元の薬局方により製造・供給されています。MSDSを含む製品情報などの詳しい情報は、発行元の薬局方のウェブサイトよりご確認ください。
Application
Levocarnitine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Other Notes
Sales restrictions may apply.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Allan M Evans et al.
Clinical pharmacokinetics, 42(11), 941-967 (2003-08-12)
L-Carnitine is a naturally occurring compound that facilitates the transport of fatty acids into mitochondria for beta-oxidation. Exogenous L-carnitine is used clinically for the treatment of carnitine deficiency disorders and a range of other conditions. In humans, the endogenous carnitine
N A Oey et al.
Placenta, 27(8), 841-846 (2005-11-23)
Carnitine plays an indispensable role in fatty acid oxidation. Previous studies revealed that fetal carnitine is derived from the mother via transplacental transfer. Recent studies demonstrated the presence and importance of an active fatty acid oxidation system in the human
Andrea Lenzi et al.
Fertility and sterility, 81(6), 1578-1584 (2004-06-15)
To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia. Placebo-controlled double-blind randomized trial. University tertiary referral center. Sixty infertile patients (aged 20-40 years) with the following baseline sperm selection criteria: concentration, 10 to 40
Sandra Wächter et al.
Clinica chimica acta; international journal of clinical chemistry, 318(1-2), 51-61 (2002-03-07)
Long-term administration of high oral doses of L-carnitine on the skeletal muscle composition and the physical performance has not been studied in humans. Eight healthy male adults were treated with 2 x 2 g of L-carnitine per day for 3
Xiaoshan Zhou et al.
PloS one, 8(3), e58843-e58843 (2013-03-19)
Thymidine kinase 2 (TK2) deficiency in humans causes mitochondrial DNA (mtDNA) depletion syndrome. To study the molecular mechanisms underlying the disease and search for treatment options, we previously generated and described a TK2 deficient mouse strain (TK2(-/-)) that progressively loses
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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