N8878
ナリジクス酸
≥98%
別名:
1,4-ジヒドロ-1-エチル-7-メチル-1,8-ナフチリジン-4-オン-3-カルボン酸, 1-エチル-1,4-ジヒドロ-7-メチル-4-オキソ-1,8-ナフチリジン-3-カルボン酸
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この商品について
実験式（ヒル表記法）:
C12H12N2O3
CAS番号:
分子量:
232.24
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
206-864-7
Beilstein/REAXYS Number:
750515
MDL number:
製品名
ナリジクス酸, ≥98%
InChI
1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-6H,3H2,1-2H3,(H,16,17)
InChI key
MHWLWQUZZRMNGJ-UHFFFAOYSA-N
SMILES string
CCN1C=C(C(O)=O)C(=O)c2ccc(C)nc12
biological source
synthetic
assay
≥98%
form
powder
mp
227-229 °C (lit.)
solubility
chloroform: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
DNA synthesis | interferes
enzyme | inhibits
Quality Level
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Application
DNA重合、(ATP依存性)DNAスーパーコイリング、染色体断片化などの細菌DNAギラーゼ依存性過程の調節(阻害)に使用されます。
General description
化学構造：キノロン
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Lucia Pallecchi et al.
Antimicrobial agents and chemotherapy, 51(8), 2720-2725 (2007-06-06)
A survey carried out in 2005 among members of a healthy population of children living in Bolivia and Peru revealed that fecal carriage of Escherichia coli strains resistant to expanded-spectrum cephalosporins was remarkably increased compared to that observed in the
Suzanne Bialek et al.
Antimicrobial agents and chemotherapy, 54(10), 4373-4378 (2010-08-04)
Cross-resistance to cefoxitin (FOX), chloramphenicol (CMP), and quinolones (nalidixic acid [NAL]) related to a putative efflux system overexpression has recently been reported for Klebsiella pneumoniae. The potential impact of this multidrug resistance (MDR) on the virulence of K. pneumoniae was
Inna Chmelnitsky et al.
Antimicrobial agents and chemotherapy, 52(8), 2962-2965 (2008-06-04)
Fourteen out of 16 carbapenem-resistant quinolone-susceptible Enterobacter cloacae isolates were found to carry qnrB2 and bla(KPC-2) genes encoded on the same plasmid. One isolate also carried the aac(6')-Ib-cr gene. Coexistence of quinolone resistance determinants and bla(KPC-2) on the same plasmid
Valeria Bortolaia et al.
Antimicrobial agents and chemotherapy, 54(4), 1623-1626 (2010-01-27)
We characterized 67 Escherichia coli isolates with reduced susceptibility to cefotaxime or ceftiofur obtained from healthy broilers housed in five Italian farms. The bla(CTX-M-1), bla(CTX-M-32) and bla(SHV-12) beta-lactamase genes were identified on IncI1, IncN, or IncFIB plasmids. Considerable genetic diversity
Kate S Baker et al.
The Lancet. Infectious diseases, 15(8), 913-921 (2015-05-06)
Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions (Africa, Asia, and Latin America). Since the 1970s, shigellosis has also been reported as a sexually transmitted infection in men who
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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