P7045
フェンホルミン 塩酸塩
analytical standard
別名:
フェネチルビグアニド
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この商品について
実験式（ヒル表記法）:
C10H15N5 · HCl
CAS番号:
分子量:
241.72
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
212-637-3
MDL number:
grade
analytical standard
Quality Level
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
Cl.NC(=N)NC(=N)NCCc1ccccc1
InChI
1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H
InChI key
YSUCWSWKRIOILX-UHFFFAOYSA-N
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関連するカテゴリー
General description
Phenformin hydrochloride is a biguanide derivative that shows anti-diabetic activity.
Application
Phenformin hydrochloride has been used as a test compound to study the antineoplastic activity it can exhibit in suppressing the growth of ovarian cancer cells and also human hepatocellular carcinoma cells.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
P7045-50G: + P7045-VAR: + P7045-BULK: + P7045-1G: + P7045-10G:
jan
Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs
Hsu C-C, et al.
Oncology Reports, 34(3), 1620-1628 (2015)
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Segal D E, et al.
Biochemical and Biophysical Research Communications, 414(4), 694-699 (2011)
Ashley J Ovens et al.
The Biochemical journal, 479(11), 1181-1204 (2022-05-14)
The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new strategies to treat type
Arindam Mondal et al.
Scientific reports, 12(1), 13135-13135 (2022-07-31)
The imidazolium compound Ym155 was first reported to be a survivin inhibitor. Ym155 potently induces cell death of many types of cancer cells in preclinical studies. However, in phase II clinical trials Ym155 failed to demonstrate a significant benefit. Studies
Mozhgan Sedigh-Ardekani et al.
Regulatory toxicology and pharmacology : RTP, 70(2), 514-518 (2014-09-10)
Lactic acidosis occurs in a number of clinical conditions, e.g. in surgeries, orthotopic liver transplant, and anesthetic agent administration, which has deleterious effects on the patient's survival. The most rational therapy for these patients, the sodium bicarbonate administration, cannot prevent
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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