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Merck

PHR1057

フロセミド

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

4-クロロ-N-フルフリル-5-スルファモイルアントラニル酸, 5-(アミノスルホニル)-4-クロロ-2-([2-フラニルメチル]アミノ)安息香酸

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この商品について

実験式（ヒル表記法）:
C12H11ClN2O5S
CAS番号:
54-31-9
分子量:
330.74
MDL number:
MFCD00010549
NACRES:
NA.24
PubChem Substance ID:
329823087
UNSPSC Code:
41116107
EC Number:
200-203-6

主要文書

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製品名

フロセミド, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. F0700000
traceable to USP 1287008

API family

furosemide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

220 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... SLC12A1(6557)

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関連するカテゴリー

Biochem/physiol Actions

腎臓におけるイオン共輸送を阻害します。

Analysis Note

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

Application

Furosemide may also be used as a reference standard in determining the concentration of furosemide present in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS). Furosemide may be used pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using diffuse reflectance spectroscopy.
Furosemide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry, spectrophotometry and high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Furosemide is a diuretic drug, which finds a variety of therapeutic applications such as hepatic cirrhosis, cardiac insufficiency and arterial hypertension.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7130 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

試験成績書（COA）

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Sensitive micro analysis of frusemide (furosemide) in bulk drug and formulations by visible spectrophotometry and high performance liquid chromatography (HPLC)
Basavaiah K and Chandrashekar U
Indian Journal of Chemical Technology, 249(1), 117-126 (2005)
Determination of furosemide in pharmaceutical formulations by diffuse reflectance spectroscopy
Gotardo AM, et al.
Talanta, 64(2), 361-365 (2004)
A novel application of immobilization on membranes for the separation and spectrofluorimetric quantification of amiloride and furosemide in pharmaceutical samples
MCP, et al.
Analytica Chimica Acta, 661(1), 85-90 (2010)
Simultaneous determination of amiloride and furosemide in pharmaceutical formulations by first digital derivative spectrophotometry
Toral MI, et al.
International Journal of Pharmaceutics, 249(1), 117-126 (2002)
Simultaneous Determination of the Diuretics Triamterene and Furosemide in Pharmaceutical Formulations and Urine by HPLC-EC
Barroso MB, et al.
Journal of Liquid Chromatography and Related Technologies, 19(2), 231-246 (1996)
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