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Merck

PHR1094

フェナセチン

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

1-アセチル-p-フェネチジン, 4′-エトキシアセトアニリド, N-(4-エトキシフェニル)アセトアミド, p-アセトフェネチジド, アセトフェネチジン

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この商品について

化学式:
CH3CONHC6H4OC2H5
CAS番号:
62-44-2
分子量:
179.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823116
EC Number:
200-533-0
Beilstein/REAXYS Number:
1869238
MDL number:
MFCD00009094

主要文書

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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1514008

API family

phenacetin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

~Approximately 135 °C

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCOc1ccc(NC(C)=O)cc1

InChI

1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

InChI key

CPJSUEIXXCENMM-UHFFFAOYSA-N

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関連するカテゴリー

General description

Phenacetin is a mild analgesic drug effective for the treatment of mild to moderate pain. Its analgesic property is comparable to that of aspirin.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Phenacetin may be used as a calibration standard for the development of a test for the evaluation of phenacetin by thermal analyzes methods.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

CYP1A2とCYP2D6の基質。

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC4010 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Muta. 2 - Skin Sens. 1 - Water-react. 2

保管分類

4.3 - Hazardous materials which set free flammable gases upon contact with water

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

名称等を表示すべき危険物及び有害物

ishl_indicated

名称等を通知すべき危険物及び有害物

ishl_notified

PHR1094-1G-BULK: + 44207-1G-BULK: + 44207-1G: + PHR1094-1G-PW: + PHR1094-1G:

jan

試験成績書（COA）

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以前この製品を購入いただいたことがある場合

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Broad range purity analysis by melting point depression using a singular feature common to all DSC purity scans
Gustin GM
Thermochimica Acta, 39(2), 81-93 (1980)
Paracetamol and phenacetin
Clissold SP
Drugs, 32(4), 46-59 (1986)
Purity and heat of fusion data for environmental standards as determined by differential scanning calorimetry
Donnelly JR, et al.
Thermochimica Acta, 167(2), 155-187 (1990)
J A Hinson
Environmental health perspectives, 49, 71-79 (1983-03-01)
Phenacetin can be metabolized to reactive metabolites by a variety of mechanisms. (1) Phenacetin can be N-hydroxylated, and the resulting N-hydroxyphenacetin can be sulfated or glucuronidated. Whereas phenacetin N-O sulfate immediately rearranges to form a reactive metabolite which may covalently
L F Prescott
British journal of clinical pharmacology, 10 Suppl 2, 291S-298S (1980-10-01)
1 The rate of absorption of oral paracetamol depends on the rate of gastric emptying and is usually rapid and complete. The mean systemic availability is about 75%. 2 Paracetamol is extensively metabolized and the plasma half-life is 1.5-2.5 hours.
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