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Merck

PHR1204

ベンゾフェノン

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

NSC 8077, ジフェニルケトン, ジフェニルメタノン

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この商品について

化学式:
(C6H5)2CO
CAS番号:
分子量:
182.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
204-337-6
Beilstein/REAXYS Number:
1238185
MDL number:
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InChI key

RWCCWEUUXYIKHB-UHFFFAOYSA-N

InChI

1S/C13H10O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H

SMILES string

O=C(C1=CC=CC=C1)C2=CC=CC=C2

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000647

vapor pressure

1 mmHg ( 108 °C)

API family

benzophenone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

305 °C (lit.)

mp

47-51 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Benzophenone is widely used in the manufacture of cosmetics and pharmaceuticals for its UV rays absorbing and fragrance retention abilities. Due to its ability to absorb ultraviolet radiations harmful in the form of UVA (320-400 nm) and UVB (290-320 nm), it is effective against skin disorders and skin cancer. It is used in the synthesis of antihistamines, hypnotics, and insecticides and is present as a potential impurity in diphenhydramine hydrochloride, phenytoin bulk powder, and phenytoin dosage forms.

Application

Benzophenone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic, spectrophotometric and polarographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3932 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Carc. 1B - STOT RE 2 Oral

target_organs

Liver,Kidney

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

280.4 °F - closed cup

flash_point_c

138 °C - closed cup


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

第一種指定化学物質

prtr

名称等を表示すべき危険物及び有害物

ishl_indicated

名称等を通知すべき危険物及び有害物

ishl_notified

PHR1204-1G: + PHR1204-1G-PW:

jan


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Polarographic determination of phenytoin and benzophenone (as impurity) in pharmaceutical preparations
Razak OA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 28(3-4), 613-619 (2002)
Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin
Walash MI, et al.
Chemistry Central Journal, 5(1), 85-85 (2011)
Separation and simultaneous high-performance liquid chromatographic determination of benzocaine and benzyl benzoate in a pharmaceutical preparation
Gigante Barbara, et al.
Journal of Chromatography A, 549(1), 217-220 (1991)
Simultaneous analysis of benzophenone sunscreen compounds in water sample by stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry
Kawaguchi M, et al.
Journal of Chromatography A, 1200(2), 260-263 (2008)
Masayuki Kyomoto et al.
Biomaterials, 34(32), 7829-7839 (2013-07-31)
We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost

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