PHR1224
6-アミノカプロン酸
Pharmaceutical Secondary Standard; Certified Reference Material
別名:
ε-アミノカプロン酸, 6-アミノヘキサン酸, EACA
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この商品について
化学式:
H2N(CH2)5CO2H
CAS番号:
分子量:
131.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-469-3
Beilstein/REAXYS Number:
906872
MDL number:
製品名
6-アミノカプロン酸, Pharmaceutical Secondary Standard; Certified Reference Material
InChI key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
SMILES string
NCCCCCC(O)=O
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to Ph. Eur. A0420000
traceable to USP 1021000
API family
aminocaproic acid
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
mp
207-209 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
Quality Level
Gene Information
human ... PLAT(5327), PLG(5340)
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Biochem/physiol Actions
リシン類縁体です。プラスミンを速やかに分解させることで、プラスミノーゲンの活性化とその後の線維素溶解を阻害します。
リシン類縁体です。プラスミンを速やかに分解させることで、プラスミノーゲンの活性化とその後の線維素溶解を阻害します。活性化血小板へのプラスミノーゲンの結合を阻害することが報告されています。初期の報告では、補体第一成分の活性化を阻害することも示されています。カルボキシペプチダーゼBに結合して不活性化させます。
Analysis Note
These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.
Application
Aminocaproic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by fluorimetry and in bulk and injectable forms using colorimetric method.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
General description
Aminocaproic acid is a synthetic inhibitor of fibrinolysis and is utilized for the control of excessive bleeding in patients with amegakaryocytic thrombocytopenia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA9036 in the slot below. This is an example certificate only and may not be the lot that you receive.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Development of Colorimetric Method for the Analysis of Aminocaproic Acid Using DCQ
Shantier SW, et al.
World Journal of Pharmaceutical Research, 4(4), 234-240 (2015)
Fluorimetric determination of aminocaproic acid in pharmaceutical formulations using a sequential injection analysis system
Pinto PCAG, et al.
Talanta, 68(3), 857-862 (2006)
The absorption, distribution, and excretion of ?-aminocaproic acid following oral or intravenous administration to man
McNicol GP, et al.
The Journal of Laboratory and Clinical Medicine, 59(1), 15-24 (1962)
Aminocaproic acid: use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia
Gardner FH and Helmer RE
JAMA : The Journal of the American Medical Association, 243(1), 35-37 (1980)
Ed M Choi et al.
Laboratory investigation; a journal of technical methods and pathology, 89(6), 624-635 (2009-05-13)
Recent cases of prion transmission in humans following transfusions using blood donated by patients with asymptomatic variant Creutzfeldt-Jakob disease (CJD) implicate the presence of prion infectivity in peripheral blood. In this study, we examined the levels of the normal, cellular
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