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Merck

PHR1227

5-フルオロウラシル

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

2,4-ジヒドロキシ-5-フルオロピリミジン, 5-FU, 5-フルオロ-2,4(1H,3H)-ピリミジンジオン

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この商品について

実験式(ヒル表記法):
C4H3FN2O2
CAS番号:
分子量:
130.08
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-085-6
Beilstein/REAXYS Number:
127172
MDL number:
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Quality Segment

grade

certified reference material, pharmaceutical secondary standard

agency

USP 12790000, traceable to Ph. Eur. F0250000

API family

fluorouracil

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

282-286 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

Gene Information

human ... TYMS(7298)

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluorouracil, an analog of the pyrimidines, belongs to the class of antimetabolite drugs. It is generally utilized for the remediation of tumors such as breast adenocarcinoma, gastrointestinal tract, ovary, head and neck.

Application

Fluorouracil may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by different analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3468 in the slot below. This is an example certificate only and may not be the lot that you receive.


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pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

名称等を表示すべき危険物及び有害物

ishl_indicated

名称等を通知すべき危険物及び有害物

ishl_notified

PHR1227-500MG:4.548173380162E12

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試験成績書(COA)

製品のロット番号またはバッチ番号を入力して、分析証明書(COA)を検索してください。ロット番号およびバッチ番号は、製品のラベル上の「Lot」または「Batch」という表記の後に記載されています。

COA(試験成績書)のサンプル

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以前この製品を購入いただいたことがある場合

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Analysis of pharmaceutical creams: a useful approach based on solid-phase extraction (SPE) and UV spectrophotometry
Bonazzi D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 13(11), 1321-1329 (1995)
Polymeric nanoparticles for oral delivery of 5-fluorouracil: Formulation optimization, cytotoxicity assay and pre-clinical pharmacokinetics study
Mattos ACD, et al.
European Journal of Pharmaceutical Sciences, 84(11), 83-91 (2016)
Analysis of flucytosine dosage forms by derivative UV spectroscopy and liquid chromatography.
Cavrini V, et al.
Journal of Pharmaceutical and Biomedical Analysis, 9(5), 401-407 (1991)