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PHR1247

インドメタシン

Name: インドメタシン
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

1-(4-クロロベンゾイル)-5-メトキシ-2-メチル-3-インドール酢酸

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この商品について

実験式（ヒル表記法）:

C₁₉H₁₆ClNO₄

CAS番号:

53-86-1

分子量:

357.79

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823251

EC Number:

200-186-5

Beilstein/REAXYS Number:

497341

MDL number:

MFCD00057095

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特性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. I0200000, traceable to USP 1341001

API family

indomethacin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

InChI key

CGIGDMFJXJATDK-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

詳細

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Indomethacin drug is extensively employed as a pharmacologic agent to bring about the closure of patent ductus arteriosus (PDA) in premature infants.

Application

Indomethacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

COX-1に比較的選択性を有するシクロオキシゲナーゼ (COX) インヒビターです。

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC0281 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P301 + P310

Hazard Classifications

Acute Tox. 1 Oral

保管分類

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA）を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Simple, rapid and sensitive method for the determination of indomethacin in plasma by high-performance liquid chromatography with ultraviolet detection

Sato J, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 692(1), 241-244 (1997)

Liquid chromatographic determination of atorvastatin in bulk drug, tablets, and human plasma

Altuntas TG and Erk N

Journal of Liquid Chromatography and Related Technologies, 27(1), 83-93 (2004)

Advantages of application of UPLC in pharmaceutical analysis.

Novakova L, et al.

Talanta, 68(3), 908-918 (2006)