PHR1290

ニフェジピン

Name: ニフェジピン
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

別名:

1,4-ジヒドロ-2,6-ジメチル-4-(2-ニトロフェニル)-3,5-ピリジンジカルボン酸ジメチルエステル

ログインで組織・契約価格をご覧ください。

サイズを選択してください

この商品について

実験式（ヒル表記法）:

C₁₇H₁₈N₂O₆

CAS番号:

21829-25-4

分子量:

346.33

NACRES:

NA.24

PubChem Substance ID:

329823282

UNSPSC Code:

41116107

EC Number:

244-598-3

MDL number:

MFCD00057326

主要文書

すべての文書を表示

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

InChI key

HYIMSNHJOBLJNT-UHFFFAOYSA-N

InChI

1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

SMILES string

COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OC

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. N0750000, traceable to USP 1463508

API family

nifedipine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)

類似した製品をお探しですか？訪問製品比較ガイド

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Nifedipine belongs to the class of calcium channel antagonist drugs and finds a wide use as an antihypertensive and an antianginal agent. It can also be used as a coronary vasodilator.

Application

Nifedipine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by spectrophotometry and chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

このような2次標準は、USP、EP（PhEur）、BPの1次標準にマルチトレーサビリティを提供します。

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA0488 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

保管分類

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

PHR1290-1G-PW: + PHR1290-1G:

jan

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA）を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Determination of nifedipine in human plasma by high-performance liquid chromatography with electrochemical detection

Suzuki H, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 341(1), 341-347 (1985)

New spectrophotometric methods for the determination of nifedipine in pharmaceutical formulations

Rahman N and Azmi SNH

Acta Biochimica Polonica, 52(4), 915-915 (2005)

Analysis of nifedipine-acebutolol hydrochloride binary combination in tablets using UV-derivative spectroscopy, capillary gas chromatography and high performance liquid chromatography.

A F el Walily

Journal of pharmaceutical and biomedical analysis, 16(1), 21-30 (1998-02-03)

Three methods are described for the simultaneous determination of nifedipine and acebutolol hydrochloride in combined pharmaceutical tablets. The first method depends on first-derivative ultraviolet spectrophotometry, with peak-to-base and zero-crossing measurements methods. The first derivative amplitudes at 400 and 352 nm

[Nifedipine: a novel vasodilator].

Norio Taira

Drugs, 66 Spec No 1, 1-3 (2008-01-19)

Nifedipine was synthesized by Bayer Germany in 1966 and considered for clinical use as a coronary vasodilator in patients with angina pectoris. Japanese investigators played a great part in the pre-clinical and clinical development of nifedipine. Professor Hashimoto demonstrated that

Long-acting dihydropyridine calcium-channel blockers and sympathetic nervous system activity in hypertension: a literature review comparing amlodipine and nifedipine GITS.

Corey B Toal et al.

Blood pressure, 21 Suppl 1, 3-10 (2012-07-06)

Calcium-channel blockers (CCBs) constitute a diverse group of compounds but are often referred to as a single homogeneous class of drug and the clinical responses indiscriminately summarized. Even within the dihydropyridine subgroup, there are significant differences in formulations, pharmacokinetics, durations

ニフェジピン

Pharmaceutical Secondary Standard; Certified Reference Material

サイズを選択してください

この商品について

主要文書

特性

InChI key

InChI

SMILES string

grade

agency

API family

CofA

technique(s)

application(s)

format

storage temp.

Quality Level

Gene Information

関連するカテゴリー

詳細

General description

Application

Analysis Note

Other Notes

安全性情報

pictograms

signalword

hcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

適用法令

PHR1290-1G-PW: + PHR1290-1G:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

テクニカルサービス