STS0200
TWEEN® 20
viscous liquid
別名:
ポリエチレングリコールソルビタンモノラウラート, ポリオキシエチレンソルビタンモノラウラート
製品名
TWEEN® 20, viscous liquid
InChI
1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
SMILES string
CCCCCCCCCCCC(=O)OCCOCC(C1C(C(CO1)OCCO)OCCO)OCCO
InChI key
HMFKFHLTUCJZJO-UHFFFAOYSA-N
description
non-ionic
assay
≥40%
form
viscous liquid
mol wt
~1228
composition
lauric acid, ≥40% (balance primarily myristic, palmitic, and stearic acids)
greener alternative product characteristics
Use of Renewable Feedstocks
Design for Degradation
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
concentration
≥40.0% (GC)
impurities
≤3.0% water
refractive index
n20/D 1.468 (lit.)
CMC
0.06 mM (20-25°C)
mp
98.9 °C
acid number
≤2.2 mg KOH/g
hydroxyl value
96‑108 mg KOH/g
transition temp
cloud point 76 °C
solubility
water: 100 mg/mL, clear, faintly yellow to yellow
density
1.095 g/mL at 25 °C (lit.)
HLB
16.7
greener alternative category
Quality Level
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関連するカテゴリー
Application
非イオン界面活性剤です。
TWEEN 20 has been used as a component of:
- washing buffer and blocking buffer in Western blotting
- blocking buffer in immunohistochemistry
- washing buffer in ELISA (enzyme linked immunosorbent assay)
- reaction mixture in PCR (polymerase chain reaction)
TWEEN 20 is a nonionic detergent widely used in biochemical applications. It has been used as an emulsifying agent for the preparation of stable oil-in-water emulsions. TWEEN 20 has been used in pre-extraction of membranes to remove peripheral proteins (used at 2% for extraction of membrane-bound proteins).
TWEEN 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%. TWEEN 20 can be used for lysing mammalian cells at a concentration of 0.005 to 0.5%.
TWEEN 20 has been used as a blocking agent for membrane based immunoassays at a typical concentration of 0.05%. TWEEN 20 can be used for lysing mammalian cells at a concentration of 0.005 to 0.5%.
Features and Benefits
- 100 % Renewable
- 100 % Bio-based
- Certified to the USDA BioPreferred Program
- Lower carbon footprint than petrochemical-based versions
- High-purity chemical suitable for a wide variety of research applications
General description
ECO TWEEN® 20, also known as Polyoxyethylenesorbitan monolaurate, is a bio-based, nonionic detergent manufactured from a natural fatty acid. This surfactant, derived from natural sources, provides various functional advantages, such as detergency, emulsification, and wetting. Its versatility makes it well-suited for a variety of applications in biochemical and biological research, with common uses including cell lysis, protein extraction, nuclei isolation and cell fractionation.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is a biobased surfactant and is aligned with the 7th principle of Green Chemistry "Use of Renewable Feedstocks" and the 10th principle "Design for Degradation".
TWEEN 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family. It is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid. The ethylene oxide subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment. Sorbitol forms the backbone ring to which the ethylene oxide polymers are attached.
TWEEN 20 is a polyoxyethylene sorbitol ester that belongs to the polysorbate family. It is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid. The ethylene oxide subunits are responsible for the hydrophilic nature of the surfactant, while the hydrocarbon chains provide the hydrophobic environment. Sorbitol forms the backbone ring to which the ethylene oxide polymers are attached.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Preparation Note
TWEEN 20 is miscible in water (100mg/mL), yielding a clear, yellow solution. It is also miscible with alcohol, dioxane, and ethyl acetate. TWEEN 20 is insoluble in liquid paraffin and fixed oils.
Legal Information
ECO TWEEN is a registered trademark of Croda Inc.
TWEEN is a registered trademark of Croda International PLC
保管分類
10 - Combustible liquids
wgk
WGK 1
flash_point_f
527.0 °F - Pensky-Martens closed cup
flash_point_c
275 °C - Pensky-Martens closed cup
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Lannetta PM et al
Physiologia Plantarum, 127.2, 247-259 (2006)
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Journal of immunology (Baltimore, Md. : 1950), 185(1), 763-768 (2010-06-04)
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Human hypoblast formation is not dependent on FGF signalling.
Roode M et al
Developmental Biology, 361(2), 358-363 (2012)
Dale Howe et al.
Methods in molecular biology (Clifton, N.J.), 445, 389-406 (2008-04-22)
Coxiella burnetii is a bacterial obligate intracellular pathogen that replicates within a spacious parasitophorous vacuole (PV) with lysosomal characteristics. The pathogen actively participates in the biogenesis of its PV by synthesizing proteins that mediate vesicular interactions. Both C. burnetii and
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Journal of agricultural and food chemistry, 56(22), 11011-11017 (2008-11-04)
St. John's wort (SJW; Hypericum perforatum L.) is commonly known for its antidepressant properties and was traditionally used to promote wound healing, but its molecular mechanism of action is not known. Here, chemical-genetic profiling in yeast was used to predict
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