15759
Poloxamer 188
別名:
ポリ(エチレングリコール)-block-ポリ(プロピレングリコール)-block-ポリ(エチレングリコール), Lutrol F68, Poloxamer 188
SMILES string
O2C(C2)C.O1CC1
InChI
1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
InChI key
RVGRUAULSDPKGF-UHFFFAOYSA-N
form
solid
mol wt
~7680-9510 g/mol
composition
oxyethylene, 79.9-83.7%
impurities
≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤1 ppm ethylene oxide
≤1.0% water
≤2 ppm arsenic traces
≤20 ppm heavy metals
≤5 ppm dioxan
≤5 ppm propylene oxide
50-150 ppm butylhydroxytoluene
ign. residue
≤0.30%
color
APHA: ≤120, 50/50 in CH3OH
pH
5.0-7.5 (100 g/L in H2O)
6.0-7.5 (25 g/L in H2O)
CMC
0.48 mM
transition temp
cloud point >100 °C
HLB
>24
Quality Level
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関連するカテゴリー
Application
- 皮膚用製剤における P 188 の安定化機能：皮膚用ヘスペリジン smartCrystals の工業用濃縮液に対する安定化効果を検証したところ、P 188 は製剤の長期安定性の向上に寄与し、皮膚治療介入に役立つことが判明しました（Romero et al., 2015）。
Biochem/physiol Actions
Poloxamer 188は、増粘剤およびゲル結合剤として広く使用されています。
Other Notes
Poloxamer 188グレードは、広範囲な一連のブロックコポリマーからのポロキサマーです。
Legal Information
保管分類
11 - Combustible Solids
wgk
WGK 1
A N Sklifas et al.
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Wanhua Feng et al.
Colloids and surfaces. B, Biointerfaces, 105, 43-50 (2013-01-29)
The interaction between bacteria and surfaces is central to many environmental, industrial and medical applications. Surfactants are commonly used in these applications and can potentially influence the bacterium/surface interaction. The effect of surfactants upon bacterial cell surface thermodynamic properties was
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