52423
デキストラン硫酸 ナトリウム塩 Leuconostoc)spp.由来
low sulfate content, Mr ~40,000
biological source
(Leuconostoc spp)
form
powder
quality
low sulfate content
mol wt
Mr ~40,000
composition
Sulfur Content, 8-13%
loss
≤10% loss on drying
color
white to off-white
useful pH range
6.0-8 (10 g/L)
solubility
H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow
storage temp.
room temp
Quality Level
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General description
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.
Application
Dextran sulfate increases binding of epithelial cells and lymphocytes to extracellular matrix proteins including fibronectin and laminin. In addition, dextran sulfate altered expreβion of cell surface receptors integrins.
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
Preparation Note
Sigma dextrans are derived from Leuconostoc mesenteroides.
Other Notes
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
52423-VAR: + 52423-BULK: + 52423-25G: + 52423-100G: + 52423-5G:
jan
J Ni et al.
Gut, 39(2), 234-241 (1996-08-01)
The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial
Jiang-Hua Liu et al.
Disease models & mechanisms, 13(11) (2020-10-10)
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and
資料
Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.
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