A3262
アデノシン 3′,5′-環状一リン酸 トリス塩
≥97% (HPLC), synthetic, powder
別名:
cAMP, サイクリックAMP
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この商品について
実験式（ヒル表記法）:
C10H12N5O6P · C4H11NO3
CAS番号:
分子量:
450.34
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.51
MDL number:
製品名
アデノシン 3′,5′-環状一リン酸 トリス塩, ≥97% (HPLC), powder
SMILES string
NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
InChI key
CLDDYJFNXTUHIN-MCDZGGTQSA-N
InChI
1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1
biological source
synthetic
assay
≥97% (HPLC)
form
powder
color
white
solubility
H2O: 100 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
天然に存在するサイクリックAMP依存性プロテインキナ-ゼ(PKA)の活性化因子です。cAMAPは、多くの系において神経伝達物質またはホルモン誘導性の受容体刺激に関与する重要なセカンドメッセンジャ-です。cAMP/PKAシグナル伝達経路は細胞増殖を阻害し、分化を誘導し、アポト-シスを引き起こすことが知られています。
Application
Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture and induced neural stem cells (iNSCs). It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.
General description
Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays. Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production. Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors
Tang X, et al.
Stem Cell Research, 16(2), 236-242 (2016)
Alexander Mueller et al.
Pain, 160(8), 1766-1780 (2019-07-25)
Pain is the leading cause of disability in the developed world but remains a poorly treated condition. Specifically, postsurgical pain continues to be a frequent and undermanaged condition. Here, we investigate the analgesic potential of pharmacological NaV1.7 inhibition in a
Cyclic AMP: master regulator of innate immune cell function
Serezani CH, et al.
American Journal of Respiratory Cell and Molecular Biology, 39(2), 127-132 (2008)
Red fluorescent protein-based cAMP indicator applicable to optogenetics and in vivo imaging
Harada K, et al.
Scientific reports, 7(1), 7351-7351 (2017)
Local cAMP signaling in disease at a glance
Gold MG, et al.
Journal of Cell Science, 126(20), 4537-4542 (2013)
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