A6140
アンピシリン 三水和物
900-1050 μg/mg anhydrous basis (HPLC)
別名:
D-(−)-α-アミノベンジルペニシリン
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この商品について
実験式（ヒル表記法）:
C16H19N3O4S · 3H2O
CAS番号:
分子量:
403.45
UNSPSC Code:
51281703
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-709-7
Beilstein/REAXYS Number:
5399534
MDL number:
製品名
アンピシリン 三水和物, 900-1050 μg/mg anhydrous basis (HPLC)
InChI key
RXDALBZNGVATNY-CWLIKTDRSA-N
InChI
1S/C16H19N3O4S.3H2O/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;;;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);3*1H2/t9-,10-,11+,14-;;;/m1.../s1
SMILES string
O.O.O.CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(O)=O
form
powder or crystals
concentration
900-1050 μg/mg (anhydrous, HPLC)
mp
198-200 °C (dec.) (lit.)
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
Biochem/physiol Actions
ペニシリン骨格の側鎖にアミノ基を持つβ-ラクタム抗生物質です。細菌の細胞膜の内側にあるトランスペプチダーゼを不活性化して細胞壁の合成(ペプチドグリカン架橋結合)を阻害するペニシリンの誘導体です。成長過程の大腸菌に対してのみ殺菌作用があります。耐性機序:β-ラクタマーゼが、アンピシリンのβ-ラクタム環を切断します。抗菌スペクトル:グラム陰性菌、グラム陽性菌。
Application
Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells.
General description
Chemical structure: ß-lactam
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
H J Nelis et al.
Antimicrobial agents and chemotherapy, 36(8), 1606-1610 (1992-08-01)
The determination of ampicillin in plasma and serum by reversed-phase high-performance liquid chromatography with UV detection suffers from poor selectivity and sensitivity. Currently, the most common approach to overcoming these problems consists of improving the compound's detectability via pre- or
Ramendra K Singh et al.
European journal of medicinal chemistry, 45(3), 1078-1086 (2009-12-26)
Curcumin bioconjugates, viz. di-O-tryptophanylphenylalanine curcumin (2), di-O-decanoyl curcumin (3), di-O-pamitoyl curcumin (4), di-O-bis-(gamma,gamma)folyl curcumin (6), C(4)-ethyl-O-gamma-folyl curcumin (8) and 4-O-ethyl-O-gamma-folyl curcumin (10) have been synthesized and tested for their antibacterial and antiviral activities. The conjugates 2, 3, 4, 6 and
Sherif A F Rostom et al.
Bioorganic & medicinal chemistry, 17(2), 882-895 (2008-12-17)
The synthesis of two groups of structure hybrids comprising basically the antipyrine moiety attached to either polysubstituted thiazole or 2,5-disubstituted-1,3,4-thiadiazole counterparts through various linkages is described. Twelve out of the newly synthesized compounds were evaluated for their anti-inflammatory activity using
Sherif A F Rostom et al.
Bioorganic & medicinal chemistry, 17(6), 2410-2422 (2009-03-03)
The azole pharmacophore is still considered a viable lead structure for the synthesis of more efficacious and broad spectrum antimicrobial agents. Potential antibacterial and antifungal activities are encountered with some tetrazoles. Therefore, this study presents the synthesis and antimicrobial evaluation
Ebtehal S Al-Abdullah et al.
European journal of medicinal chemistry, 46(9), 4642-4647 (2011-08-19)
New series of 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles namely, 2-substitued thio-6-phenyl-3,4-dihydro-4-oxopyrimidine-5-carbonitriles (5a-d, 6, 7a-d, 8), 2-(4-chlorobenzylthio)-4-chloro-6-phenylpyrimidine-5-carbonitrile (9), 2-(4-chlorobenzylthio)-4-arylthio-6-phenylpyrimidine-5-carbonitriles (10a-d) and 2-(4-chlorobenzylthio)-4-arylamino-6-phenylpyrimidine-5-carbonitriles (11a-d) was synthesized and tested for in vitro activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus
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