C127
CNQX
≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid
別名:
6-シアノ-7-ニトロキノキサリン-2,3-ジオン, FG-9065
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この商品について
実験式（ヒル表記法）:
C9H4N4O4
CAS番号:
分子量:
232.15
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
CNQX, ≥98% (HPLC), solid
SMILES string
[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N
InChI
1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
InChI key
RPXVIAFEQBNEAX-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow
solubility
DMSO: >10 mg/mL
H2O: insoluble
Quality Level
Gene Information
rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)
Application
CNQXは、次の用途で使用されています：
- 多能性胚性幹細胞（pESC）におけるαcytoneme（サイトネーム）形成に対するその効果を調べるためのロキシ-5-メチル-4-イソキサゾールプロピオン酸（AMPA）/カイニン酸ブロッカーとして
- 中枢触覚葉ニューロンにおける電流クランプ記録中のシナプス入力を低下させるためのグルタミン酸ブロッカーとして
- ラットにおける心臓に対するその効果を調べるための非N-メチル-D-アスパラギン酸（NMDA）受容体ブロッカーとして
Biochem/physiol Actions
AMPA/カイニン酸受容体の強力な競合的アンタゴニストです。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Guan Hock Khoo et al.
Molecular neurobiology, 56(9), 6436-6450 (2019-03-04)
Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Ira Espuny-Camacho et al.
Neuron, 77(3), 440-456 (2013-02-12)
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
Julia Pose-Utrilla et al.
Nature communications, 8(1), 2275-2275 (2017-12-24)
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. Unexpectedly, we find
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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