C3237
抗カベオリン-1抗体 ウサギ宿主抗体
IgG fraction of antiserum, buffered aqueous solution
別名:
抗カベオリン1, 抗VIP21抗体
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この商品について
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, WB
Citations:
26
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 22 kDa
species reactivity
human, rat, mouse
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
indirect immunofluorescence: 1:500 using mouse fibroblast NIH3T3 cell line, microarray: suitable, western blot: 1:2,000 using whole cell extract of the human umbilical vein endothelial HUVEC cell line and the rat fibroblast Rat-1 cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
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関連するカテゴリー
General description
Anti-Caveolin-1 is developed in rabbit using a synthetic peptide corresponding to a region at the N-terminus of human caveolin-1 conjugated to keyhole limpet hemocyanin (KLH) as immunogen. Caveolin-1 (CAV1) is a multifunctional scaffolding protein, that has three exons. It is located on chromosome 7q31.
Caveolin, a 20-24-kDa integral transmembrane protein, has been identified as a principal component of caveolae membranes. Caveolin (also termed VIP21) exists in several isoforms termed caveolin-1, caveolin-2 and caveolin-3. Caveolin-1 (20-22 kDa) can exist as two isoforms, caveolin-1α and -1β due to alternative splicing of the mRNA.
Immunogen
ヒトカベオリン-1のN末端領域(アミノ酸2-20)に相当する合成ペプチド。
Application
Anti-Caveolin-1 antibody produced in rabbit has been used in:
- indirect immunofluorescence
- in confocal microscopy
- western blotting
Biochem/physiol Actions
この配列はラット, マウス, ウシ, イヌのカベオリン-1と同一であり、多くの生物種で高度に保存されています。また、この配列はカベオリン-2, カベオリン-3には存在しません。
Caveolin family members function as scaffolding proteins to organize and concentrate specific lipids such as cholesterol and glycosylphosphatidylinositol (GPI) and lipid modified signaling molecules within caveolae membranes. Staining of caveolin-1 in immunoblotting is specifically inhibited with caveolin-1 immunizing peptide (human, amino acids 2-20).†
Caveolin-1 is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters.
Physical form
0.01M PBS溶液 (pH 7.4, 15mMアジ化ナトリウム含有)。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
C3237-VAR: + C3237-BULK: + IXO11350: + C3237-200UL: + C3237-50UL:
jan
Zui Pan et al.
The Journal of biological chemistry, 279(19), 19387-19390 (2004-03-25)
Perturbation of intracellular Ca2+ homeostasis has been shown to regulate the process of cell proliferation and apoptosis. Our previous studies show that mitsugumin 29 (MG29), a synaptophysin-related protein localized in the triad junction of skeletal muscle, serves an essential role
Camila de Souza Palma et al.
Molecular & cellular proteomics : MCP, 15(3), 906-917 (2016-01-15)
Epithelial to mesenchymal transition (EMT)(1) occurs naturally during embryogenesis, tissue repair, cancer progression, and metastasis. EMT induces cellular and microenvironmental changes resulting in loss of epithelial and acquisition of mesenchymal phenotypes, which promotes cellular invasive and migratory capabilities. EMT can
Rac1 participates in thermally induced alterations of the cytoskeleton, cell morphology and lipid rafts, and regulates the expression of heat shock proteins in B16F10 melanoma cells
Gungor B, et al.
Testing, 9(2), e89136-e89136 (2014)
Co-expression of MG29 and Ryanodine Receptor Leads to Apoptotic Cell Death EFFECT MEDIATED BY INTRACELLULAR Ca2+ RELEASE
Pan Z, et al.
The Journal of Biological Chemistry, 279(19), 19387-19390 (2004)
Burcin Gungor et al.
PloS one, 9(2), e89136-e89136 (2014-03-04)
Eukaryotic cells exhibit a characteristic response to hyperthermic treatment, involving morphological and cytoskeletal alterations and the induction of heat shock protein synthesis. Small GTPases of the Ras superfamily are known to serve as molecular switches which mediate responses to extracellular
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