C4292
セフォペラゾン ナトリウム塩
870 - 1015 μg/mg anhydrous basis
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この商品について
実験式（ヒル表記法）:
C25H26N9NaO8S2
CAS番号:
分子量:
667.65
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
263-751-5
Beilstein/REAXYS Number:
4902135
MDL number:
製品名
セフォペラゾン ナトリウム塩, 870 - 1015 μg/mg anhydrous basis
InChI key
NCFTXMQPRQZFMZ-WERGMSTESA-M
InChI
1S/C25H27N9O8S2.Na/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2;/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41);/q;+1/p-1/t15-,16-,22-;/m1./s1
SMILES string
[Na+].CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C([O-])=O)c5ccc(O)cc5)C(=O)C1=O
assay
870-1015 μg/mg (anhydrous basis)
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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関連するカテゴリー
Application
セフォペラゾンは、細胞壁合成中のペニシリン結合タンパク質（PBP）の薬物-タンパク質結合、発現および阻害の研究に使用されています。
Biochem/physiol Actions
セフォペラゾンは、細菌の細胞壁の構造に影響を与えるムコペプチド合成を阻害することにより、殺菌効果を発揮します。二重の排泄パターンがあり、1つは胆道系経由、もう1つは腎臓経由での排泄です。
General description
化学構造：ß-ラクタム
Other Notes
容器は密閉し、乾燥した換気のよい場所で保管してください。乾燥した場所で保管してください。
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
B Gonik et al.
Antimicrobial agents and chemotherapy, 30(6), 874-876 (1986-12-01)
Limited pharmacokinetic data for cefoperazone are available from the parturient. Because cefoperazone has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney, pregnancy-induced physiologic alterations can influence its deposition and clearance. Twelve term parturients receiving
A Meulemans
Antimicrobial agents and chemotherapy, 36(2), 295-298 (1992-02-01)
The apparent diffusion coefficient of a bound drug, cefoperazone, was studied. The protein binding of cefoperazone was studied by voltammetry, a technique which permitted instant measurements. The apparent diffusion coefficients were similar in agar and fibrin and lower in rat
Andrea T Fessler et al.
Veterinary microbiology, 157(1-2), 226-231 (2011-12-23)
The correct assessment of mastitis pathogens for their susceptibility/resistance to cefoperazone is currently hampered by the lack of harmonized test conditions and interpretive criteria. The aim of this study was to provide a proposal for clinical breakpoints of cefoperazone which
Jung-Whan Chon et al.
Applied and environmental microbiology, 78(5), 1624-1626 (2012-01-03)
Modified charcoal-cefoperazone-deoxycholate agar (mCCDA) was improved by supplementation with a high concentration of polymyxin B. The ability of the supplemented medium to isolate Campylobacter jejuni and C. coli from chicken carcass rinses was compared to that of Campy-Cefex agar and
Ke Ni et al.
PloS one, 7(7), e41104-e41104 (2012-07-31)
Regulatory T cells (Treg cells), which are essential for regulation of immune response to respiratory syncytial virus (RSV) infection, are promoted by pharyngeal commensal pneumococcus. The effects of pharyngeal microflora disruption by antibiotics on airway responsiveness and relative immune responses
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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