C4859
シクロヘキシミド 溶液
Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture
別名:
CHX
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この商品について
実験式（ヒル表記法）:
C15H23NO4
CAS番号:
分子量:
281.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
製品名
シクロヘキシミド 溶液, Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
SMILES string
O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
biological source
microbial
description
suitable for testing specifications (CHO C. growth inhibitor)
form
ready-to-use solution
concentration
100 mg/mL in DMSO
solubility
DMSO: soluble
antibiotic activity spectrum
fungi
yeast
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Quality Level
Gene Information
human ... FKBP1A(2280), PIN1(5300)
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関連するカテゴリー
Biochem/physiol Actions
Cyclohexamide(CHX)はS. griseusが産生する抗生物質です。主要な生物学的作用は真核生物における翻訳の阻害で、その結果、細胞成長停止や細胞死を引き起こします。CHXは、酵母や真菌のCHX耐性株を選択する目的や、タンパク質合成を操作的に阻害して短寿命なタンパク質を検出したりタンパク質発現を過誘導したりする目的、さらには細胞死受容体によるアポト-シスを誘導または誘導促進する目的で広く用いられています。
細胞成長停止、Cyclohexamide耐性酵母の選択、アポト-シス誘導、FasLによるアポト-シス誘導の促進について試験済み。
Other Notes
乾燥した十分に換気された場所で容器を密閉しておきます。開けた容器は慎重に再度密封し、漏れを防ぐためにまっすぐに立てます。吸湿性。保存クラス（TRGS 510）：非可燃性、急性毒性カテゴリ1および2/毒性がきわめて高い危険物質。
Application
Cycloheximide solution has been used:
- to study its role in modulating cell death induced by tumor necrosis factor α (TNFα) in combination with the second mitochondria-derived activator of caspases (SMAC) mimetic birinapant or interferon-gamma (IFNγ), specifically under conditions that inhibit caspase-8 activity
- in the study to inhibit protein translation during the CHX-chase assays
- to treat antisense oligonucleotide (AON) transfected patient-derived fibroblasts and inhibit the nonsense-mediated decay (NMD) pathway to analyze the therapeutic potential AON and visualize the transcript containing the pseudoexon (PE)
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Muta. 2 - Repr. 1B - Skin Irrit. 2
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
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ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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