C6499
CTB
≥98% (HPLC)
別名:
N-(4-クロロ-3-トリフルオロメチル-フェニル)-2-エトキシ-ベンズアミド;N-[4-クロロ-3-(トリフルオロメチル)フェニル]-2-エトキシ-ベンズアミド;
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この商品について
実験式（ヒル表記法）:
C16H13ClF3NO2
CAS番号:
分子量:
343.73
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
製品名
CTB, ≥98% (HPLC)
InChI key
YDXZSNHARVUYNM-UHFFFAOYSA-N
SMILES string
FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CTPBは、ヒストンアセチルトランスフェラーゼp300のアクチベーターとして初めて知られた低分子化合物です。CTBは、CTPBと同程度かあるいはそれ以上の活性を発揮するCTPBの単純化アナログです。この化合物は、p300/EP300/E1A結合タンパク質のHAT活性を賦活化します。現在、その他HATアクチベーターは取り扱っておりません。
ヒストンアセチルトランスフェラーゼ(HAT)p300/CBP(CREB結合タンパク質)のアクチベーターです。
Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.
Application
CTB has been used to study its apoptotic effects on P53 protein acetylation.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
General description
CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.
保管分類
11 - Combustible Solids
wgk
WGK 2
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2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, 2 (2013)
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資料
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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