D4268
NG,NG-ジメチルアルギニン 二塩酸塩
≥98% (TLC), powder, NOS inhibitor
別名:
asym-ジメチルアルギニン, ADMA
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この商品について
実験式（ヒル表記法）:
C8H18N4O2 · 2HCl
CAS番号:
分子量:
275.18
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
NG,NG-ジメチルアルギニン 二塩酸塩,
SMILES string
Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O
InChI
1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
InChI key
SYLNVYJOPZWPJI-ILKKLZGPSA-N
assay
≥98% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
room temp
Quality Level
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
Application
NG,NG-ジメチルアルギニン二塩酸塩の用途：
- この化合物のラットにおける延髄吻側腹外側部（RVLM）の心血管の活動に対する影響の研究
- L-アルギニンおよびジメチルアルギニン測定用の標準物質
- この化合物の肝悪化に対する影響の研究
Biochem/physiol Actions
in vivo およびin vitroにおいて、一酸化窒素合成酵素の可逆的インヒビタ-です。
General description
NG,NG-ジメチルアルギニン二塩酸塩は、肝臓によって産生されるメチル化アルギニン誘導体です。この化合物は、肝硬変、アルコール性肝炎および急性肝不全（ALF）に関連しています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Marie Rodling Wahlström et al.
SpringerPlus, 3, 98-98 (2014-03-07)
A prospective, randomised, double-blinded, clinical trial was performed at a level 1 trauma centre to determine if a prostacyclin analogue, epoprostenol (Flolan®), could attenuate systemic inflammatory response in patients with severe traumatic brain injury (TBI). 46 patients with severe TBI
Kyoung Min Kim et al.
Cardiovascular diabetology, 16(1), 146-146 (2017-11-11)
The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular
Aleksandar Radujkovic et al.
Haematologica, 104(4), 827-834 (2018-12-06)
Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant
José D Martins et al.
Journal of the American Heart Association, 8(7), e011536-e011536 (2019-04-02)
Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment)
Tse-Min Lu et al.
Atherosclerosis, 254, 161-166 (2016-10-17)
Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA
資料
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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