E4013
モノクロナール抗エラスチン マウス宿主抗体
clone BA-4, ascites fluid
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この商品について
Conjugate:
unconjugated
Clone:
BA-4, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
microarray
microarray
Species reactivity:
human, goat, sheep, guinea pig, pig, canine, feline, bovine
Citations:
33
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using sheep arterial tissue
microarray: suitable
microarray: suitable
Uniprot accession no.:
製品名
モノクロナール抗エラスチン マウス宿主抗体, clone BA-4, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
BA-4, monoclonal
mol wt
antigen 67.5 kDa
contains
15 mM sodium azide
species reactivity
human, goat, sheep, guinea pig, pig, canine, feline, bovine
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:5,000 using sheep arterial tissue
microarray: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ELN(2006)
関連するカテゴリー
Biochem/physiol Actions
本抗体は不溶性エラスチン、α-エラスチン、トロポエラスチン (エラスチンの非架橋可溶性前駆体) 、不溶性エラスチンのタンパク質分解で生じるペプチドフラグメントに結合します。トロポエラスチ調製物の場合、エラスチンの3つのアイソフォ-ムに対応する3本のバンド (67.5kDa, 65kDa, 62kDa) を検出します。この抗体はエラスチンの繰返し配列から構成されるエピト-プ (Val-Gly-Val-Ala-Pro-Gly) に特異的です。このエピト-プは線維芽細胞および単球に対する化学誘引物質であることが示されています。
Elastin is encoded by the ELN gene in humans. It is a polymeric protein in connective tissue that has exceptional properties of extension, elastic recoil to the extracellular matrix and allows many tissues in the body to resume their shape after stretching or contracting. Elastin is a self-assembling, extracellular-matrix protein providing tissue elasticity and is predominantly comprised of cross-linked tropoelastin. It plays an important role in the atherosclerotic process. The conformational disorder is caused due to a constitutive feature of elastin structure and function.
Elastin undergoes changes of morphology with aging and in many disease states. For example, abnormal accumulation of connective tissue in blood vessels contributes to alterations in vascular physiology associated with diseases such as hypertension and atherosclerosis. Several heritable diseases such as Marfan syndrome, pseudoxanthoma elasticum and the Buschke-Ollendorf syndrome may result from molecular defects of elastin.
Immunogen
ウシα-エラスチン
Application
Monoclonal Anti-Elastin antibody produced in mouse has been used in:
- immunohistochemistry
- immunostaining
- immunoblotting
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Elastin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Elastin is an important polymeric protein of connective tissue. It is synthesized and secreted as a soluble single-chain protein (tropoelastin) that undergoes numerous post-ribosomal modifications prior to the organization of the elastic fiber in the extracellular space.
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保管分類
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
E4013-.5ML: + E4013-BULK: + E4013-100UL: + E4013-25UL: + E4013-.2ML: + E4013-VAR:
jan
Fabricated elastin
Yeo GC, et al.
Advanced Helathcare Materials, 4(16), 2530-2530 (2015)
Moetaz El-Domyati et al.
The Journal of clinical and aesthetic dermatology, 3(12), 22-30 (2011-01-05)
Electro-optical synergy technology is one of the most recently described methods for nonablative skin rejuvenation. The aim of this study is to evaluate the effects of electro-optical synergy on connective tissue composition by histological and immunohistochemical techniques coupled with computerized
Moetaz El-Domyati et al.
International journal of dermatology, 51(8), 913-919 (2012-07-14)
Mesotherapy, commonly known as "biorejuvenation" or "biorevitalization", is a technique used to rejuvenate the skin by means of a transdermal injection of a multivitamin solution and natural plant extracts that are thought to improve the signs of skin aging. This
Moetaz El-Domyati et al.
Journal of cosmetic dermatology, 11(2), 122-130 (2012-06-08)
As the demand for minimally invasive rejuvenation is increasing, micropeel resurfacing using Erbium:Yttrium Aluminum Garnet (Er:YAG) laser 2940 nm has been reported for the treatment of photoaged skin without ablation of the epidermis. However, little is known about the efficacy
Kinon Chen et al.
Annals of biomedical engineering, 42(3), 678-684 (2013-11-16)
Age-related macular degeneration (AMD) etiology is unknown, but its association to atherosclerotic vascular disease (ASVD) has been observed. Since elastin plays an important role in the atherosclerotic process, to understand ASVD and AMD's relationship we examined retinal elastin existence, elastin
関連コンテンツ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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