F1016
フェノテロール 臭化水素酸塩
adrenoceptor agonist
別名:
2-(3,5-ジヒドロキシフェニル)-2-ヒドロキシ-2′-(4-ヒドロキシフェニル)-1′-メチルジエチルアミン 臭化水素酸塩
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この商品について
実験式（ヒル表記法）:
C17H21NO4 · HBr
CAS番号:
分子量:
384.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
217-742-8
MDL number:
Quality level:
製品名
フェノテロール 臭化水素酸塩,
InChI key
SGZRQMALQBXAIQ-UHFFFAOYSA-N
InChI
1S/C17H21NO4.BrH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H
SMILES string
Br[H].CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2
originator
Boehringer Ingelheim
Quality Level
Gene Information
human ... ADRB2(154)
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Biochem/physiol Actions
β2-アドレナリンレセプタ-アゴニストであり、気管支拡張薬です。
Application
Fenoterol hydrobromide has been used in chromatography-tandem mass spectrometry (LC&-MS-MS) for specific and sensitive detection of β-agonists (BAG).
Features and Benefits
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Fenoterol hydrobromide is a sympathomimetic drug. It is used to treat asthma, bronchitis and emphysema. Fenoterol administration might be linked to liver damage. It has anti-inflammatory effects on eosinophil function.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
保管分類
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
F1016-1G: + F1016-BULK: + F1016-250MG: + F1016-VAR: + F1016-100MG:
jan
Krzysztof Jozwiak et al.
Chirality, 23 Suppl 1, E1-E6 (2011-05-28)
The β(2) adrenergic receptor (β(2)-AR) is a model system for studying the ligand recognition process in G protein-coupled receptors. Fenoterol (FEN) is a β(2)-AR selective agonist that has two centers of chirality and exists as four stereoisomers. Radioligand binding studies
Hegui Wang et al.
PloS one, 7(9), e46186-e46186 (2012-10-03)
Increasing evidence indicates that the rapid component of delayed rectifier potassium current (I(Kr)) is modulated by α- and β-adrenergic stimulation. However, the role and mechanism regulating I(Kr) through β(2)-adrenoreceptor (β-AR) stimulation in heart failure (HF) are unclear. In the present
Joanne Chung Yan Yeung et al.
Analytica chimica acta, 742, 37-44 (2012-08-14)
In vivo solid-phase microextraction (SPME) can be used to sample the circulating blood of animals without the need to withdraw a representative blood sample. In this study, in vivo SPME in combination with liquid-chromatography tandem mass spectrometry (LC-MS/MS) was used
T Katsunuma et al.
American journal of respiratory cell and molecular biology, 21(3), 409-417 (1999-08-26)
Neurokinin A (NKA) induces bronchoconstriction mediated by tachykinin NK(2) receptors in animals and humans, and may be increased in asthma. Because beta(2)-adrenoceptor agonists are the most widely used bronchodilators in asthma, we investigated the effects of the beta(2)-adrenoceptor agonist fenoterol
Ka-Pan Lam et al.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 22(4), 431-439 (2011-02-16)
Short-acting β2-adrenoreceptor agonist (SABA) is the major asthma reliever as indicated in the GINA guidelines. Regulated on activation, normal T expressed and secreted (RANTES) is a chemokine that attracts eosinophils, mast cells, and basophils toward site of allergic inflammation. Interferon
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