フェリチン ヒト肝臓由来由来

あらゆる組織に偏在し、鉄代謝に重要な役割を果たす鉄貯蔵タンパク質です。特に脾臓, 肝臓, 腸管粘膜, 骨髄で細胞内鉄貯蔵庫として働き、鉄の解毒に寄与します。研究から、フェリチンへの鉄の取り込みがフェリチンHサブユニットに関連するフェロキシダーゼ活性と、フェリチンLサブユニットに関連する核形成中心により調節されることが示されています。フェリチンからの鉄の放出は、鉄依存性脂質過酸化に不可欠な役割を果たしており、in vivoでのフリーラジカル誘導性細胞損傷の原因であるとみられています。そのため、フェリチンは鉄との結合により抗酸化剤として作用します。

A ubiquitous iron storage protein that plays a key role in iron metabolism. It serves as an intracellular iron reserve (particularly in spleen, liver, intestinal mucosa, and bone marrow) and functions in iron detoxification.

Ferritins are part of the host defense system and play a role in response to viral infection in animals. The abnormal levels of ferritin are correlated to many tumors associated with the prostate, breast and brain. High levels of ferritin are implicated in inflammation and macrophage activation syndrome (MAS). Mutations in the light subunit chain can lead to the neurodegenerative disease, hereditary ferritinopathy.

10 mM Tris溶液および150 mM NaCl溶液(pH 8.0, 0.1% アジ化ナトリウム含有 )。

Ferritin from human liver has been used as model protein in size-exclusion high-performance liquid chromatography technique and for synthetic nanopore translocation studies. It has also been used to test its effect on the susceptibility of shrimp (Litopenaeus vannamei) to the white spot syndrome virus.

Ferritin comprises 24-subunit and belongs to the ferritin-like diiron-carboxylate protein superfamily. Ferritin exists as heavy (H) and light (L) subunits. Liver ferritin is majorly L subunit and the spleen has the H submit. The L subunit is mapped to human chromosome 9q13.33 and the H subunit 11q12.3.