F8423
Fluorouracil
meets USP testing specifications
別名:
5-フルオロウラシル, 2,4-ジヒドロキシ-5-フルオロピリミジン, 5-FU, 5-フルオロ-2,4(1H,3H)-ピリミジンジオン
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この商品について
実験式（ヒル表記法）:
C4H3FN2O2
CAS番号:
分子量:
130.08
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
EC Number:
200-085-6
Beilstein/REAXYS Number:
127172
MDL number:
Quality level:
InChI key
GHASVSINZRGABV-UHFFFAOYSA-N
InChI
1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
SMILES string
FC1=CNC(=O)NC1=O
agency
USP/NF, meets USP testing specifications
Quality Level
Gene Information
human ... TYMS(7298)
mp
282-286 °C (dec.) (lit.)
application(s)
pharmaceutical (small molecule)
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関連するカテゴリー
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
適用法令
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名称等を表示すべき危険物及び有害物
ishl_indicated
名称等を通知すべき危険物及び有害物
ishl_notified
F8423-BULK: + F8423-10G: + F8423-5G: + F8423-250MG: + F8423-VAR:
jan
Aurélien Montagu et al.
European journal of medicinal chemistry, 46(2), 778-786 (2011-01-15)
The synthesis and antiviral evaluation of a series of C5-(1,4- and 1,5-disubstituted-1,2,3-triazolo)-nucleoside derivatives is described. The key steps of this synthesis are regioselective Huisgen's 1,3-dipolar cycloaddition, using either copper-catalyzed azide-alkyne cycloaddition (CuAAC) or ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC) under microwave activation.
Julia K J Ahlskog et al.
Bioorganic & medicinal chemistry letters, 19(16), 4851-4856 (2009-07-21)
We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of
Zhiyang Chen et al.
Nature communications, 6, 6808-6808 (2015-04-17)
Wild-type p53-induced phosphatase 1 (Wip1) negatively regulates several tumour suppressor and DNA damage response pathways. However, the impact of Wip1 on haematopoietic stem cell (HSC) homeostasis and aging remains unknown. Here we show that Wip1 is highly expressed in HSCs
Umashankar Das et al.
European journal of medicinal chemistry, 42(1), 71-80 (2006-09-26)
The 3,5-bis(arylidene)-4-piperidones 1 contain the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore which is considered to interact at a complementary binding site in susceptible neoplasms. The hypothesis was formulated that the presence of an acyl group attached to the piperidyl nitrogen atom in series 1
Umashankar Das et al.
Journal of medicinal chemistry, 54(9), 3445-3449 (2011-04-01)
Novel 3,5-bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones (3a-e) display potent cytotoxicity and a preferential lethality toward various neoplasms compared to some normal cells. The corresponding sulfonic acid analogues 5a-e and an isostere 4 demonstrated substantially lower activity. The leads 3d and 3e possess very high
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