F8807
FM19G11
≥98% (HPLC)
別名:
3-[(2,4-ジニトロベンゾイル)アミノ]-安息香酸2-(4-メチルフェニル)-2-オキソエチルエステル, [2-オキソ-2-(p-トリル)エチル]3-[(2,4-ジニトロベンゾイル)アミノ]安息香酸
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この商品について
実験式（ヒル表記法）:
C23H17N3O8
CAS番号:
分子量:
463.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
FM19G11, ≥98% (HPLC)
InChI
1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
SMILES string
Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
InChI key
XVUOIWIIQVGWAJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white to light brown
solubility
DMSO: ≥40 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
FM19G11は、低酸素誘導因子α(HIFα)の阻害薬であり、幹細胞の自己再生と分化に影響することが報告されています。
FM19G11は、低酸素誘導因子α(HIFα)の阻害薬であり、幹細胞の自己再生と分化に影響することが報告されています。低酸素誘導因子(HIF)は、細胞環境内の利用可能な酸素の変化に応答する転写因子です。他の機能(血管新生など)のなかでも、HIFαタンパク質は幹細胞の自己再生と分化の過程に影響します。FM19G11は、成体幹細胞または胚性幹細胞(ESC)モデルのほか、多様な腫瘍細胞株において、2つのαサブユニットからなる標的遺伝子を抑制するHIFαタンパク質を阻害します。
Application
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Sung Ji Choi et al.
PloS one, 8(3), e58662-e58662 (2013-03-23)
Although both glucose deprivation and hypoxia have been reported to promote cascades of biological alterations that lead to induction of inflammatory mediators, we hypothesized that glucose deprivation and hypoxia might show neutral, synergistic or antagonistic effects to each other on
UV-protection timer controls linkage between stress and pigmentation skin protection systems
Malcov B, et al.
Molecular Cell, 72(3), 444-456 (2018)
Chao-Guo You et al.
Cancer medicine (2018-05-16)
FM19G11 is a small molecular agent that inhibits hypoxia-inducible factor-1-alpha (HIF-1α) and other signaling pathways. In this study, we characterized the modulating effects of FM19G11 on O6 -methylguanine DNA-methyltransferase (MGMT), the main regulator of temozolomide (TMZ) resistance in glioblastomas. This
Kazuhiko Yamamura et al.
Nature communications, 8, 13946-13946 (2017-01-10)
Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4
Kacper A Wojtal et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(7), G673-G688 (2014-06-28)
Solute carrier (SLC) transporters mediate the uptake of biologically active compounds in the intestine. Reduced oxygenation (hypoxia) is an important factor influencing intestinal homeostasis. The aim of this study was to investigate the pathophysiological consequences of hypoxia on the expression
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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