抗グルタメート受容体NMDAR1 (NR1) ウサギ宿主抗体

N-methyl-D-aspartate receptors (NMDAR1) is mainly expressed in mammalian brain. The gene is located on human chromosome 9q34.3.

NMDAR1 is a subunit of N-methyl D-aspartate (NMDA) receptor which is a subtype of glutamate-gated ion channels with high calcium permeability. NMDA receptors have unique voltage-dependent sensitivity to magnesium and are modified by glycine. It has a pivotal role in neuronal development, pathogenesis of acute and chronic neurodegenerative disorders, synaptic plasticity as well as memory acquisition and learning. Anti-glutamate receptor NMDAR1 (NR1) antibody can be used for studying the expression and function of NMDAR1 in different cell types and tissues as well as to compare its expression pattern with physiological functions or pathological conditions. Rabbit anti-glutamate receptor NMDAR1 (NR1) antibody reacts specifically with NMDAR1 (116kD) derived from rat brain.

ラットNMDAR1のC末端領域(アミノ酸918-938)に相当する合成ペプチド。この配列は、マウスNR1、ヒトNR1(短鎖および長鎖型)、ラットNR1のNR1b・NR1c・NR1fアイソフォ-ムで一致しています。

Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit has been used in endogenous calmodulin co-immunoprecipitation and immunoprecipitation.

Anti-glutamate receptor NMDAR1 (NR1) antibody can be used as a primary antibody in western blotting. It can also be used to identify NR1 from rat brain synaptosomal fraction by using immunoblotting.

N-methyl-D-aspartate receptor1 (NMDAR1) regulates excitatory synaptic transmission. Abnormal functioning of this receptor is associated with epilepsy and schizophrenia.

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