H0163
Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal
clone HDAC4-144, purified from hybridoma cell culture
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この商品について
Conjugate:
unconjugated
Clone:
HDAC4-144, monoclonal
Application:
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Species reactivity:
human, rat, mouse
Citations:
10
Technique(s):
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using total cell extracts of NIH3T3 fibroblasts cells
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using total cell extracts of NIH3T3 fibroblasts cells
Uniprot accession no.:
製品名
Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal, clone HDAC4-144, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
HDAC4-144, monoclonal
form
buffered aqueous solution
mol wt
antigen ~140 kDa
species reactivity
human, rat, mouse
enhanced validation
independent
Learn more about Antibody Enhanced Validation
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using total cell extracts of NIH3T3 fibroblasts cells
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)
関連するカテゴリー
Application
Anti-Histone Deacetylase 4 (HDAC4) antibody, Mouse monoclonal has been used in:
- enzyme linked immunosorbent assay (ELISA)
- immunoblotting
- immunocytochemistry
- immunoprecipitation
Biochem/physiol Actions
Histone deacetylase (HDAC) catalyzes the deacetylation of histones. HDAC4 is implicated in transcriptional repression. It dynamically migrates between nucleus and cytoplasm through its nuclear import and export signals. Interaction of HDAC4 with 14-3-3 and myocyte enhancer factor-2 (Mef2) proteins disturbs such shuttling and thus directs HDAC4 to the cytoplasm and the nucleus, respectively.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Histone Deacetylase 4 (HDAC4) (mouse IgG2a isotype) is derived from the HDAC4-144 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human HDAC4 with C-terminal added lysine, conjugated to KLH. HDAC4 belongs to the class II of Mammalian HDACs.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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保管分類
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
H0163-200UL: + H0163-BULK: + H0163-VAR:
jan
Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Seto E, et al.
Cold Spring Harbor Perspectives in Biology, 6 (2014)
Pan Luo et al.
Brain research bulletin, 156, 50-57 (2020-01-11)
Cerebral ischemia-reperfusion (I/R) can trigger neuronal death through several biologically plausible pathways, but its underlying neurobiological mechanisms remain unclear. In this study, we tested whether hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) is altered in I/R that contributes to neuron damage
Yali Kong et al.
Molecular cancer therapeutics, 10(9), 1591-1599 (2011-06-24)
Inhibitors of histone deacetylases (HDAC) are an important emerging class of drugs for the treatment of cancers. HDAC inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinations with chemotherapies and radiation therapy. Although
Histone deacetylase 4 possesses intrinsic nuclear import and export signals
Wang AH, et al.
Molecular and Cellular Biology, 21, 5992-6005 (2001)
Chi Ma et al.
The Journal of biological chemistry, 286(6), 4819-4828 (2010-12-02)
Histone deacetylase (HDAC) 7 is a member of the HDAC family of deacetylases. Although some of the HDAC proteins have been shown to regulate neuronal survival and death, whether HDAC7 has a similar role is not known. In this study
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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