H7768
12(S)-ヒドロキシ-(5Z,8Z,10E,14Z)-エイコサテトラエン酸
~100 μg/mL in ethanol, ≥95% (HPLC)
別名:
(S)-12-HETE
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この商品について
実験式（ヒル表記法）:
C20H32O3
CAS番号:
分子量:
320.47
UNSPSC Code:
12352106
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-578-6
Beilstein/REAXYS Number:
2656104
MDL number:
製品名
12(S)-ヒドロキシ-(5Z,8Z,10E,14Z)-エイコサテトラエン酸, ~100 μg/mL in ethanol, ≥95% (HPLC)
InChI key
ZNHVWPKMFKADKW-LQWMCKPYSA-N
InChI
1S/C20H32O3/c1-2-3-4-5-10-13-16-19(21)17-14-11-8-6-7-9-12-15-18-20(22)23/h7-11,13-14,17,19,21H,2-6,12,15-16,18H2,1H3,(H,22,23)/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1
SMILES string
CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O
assay
≥95% (HPLC)
form
liquid
concentration
~100 μg/mL in ethanol
shipped in
dry ice
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
12(S)-HETEは、腫瘍細胞株や動物モデルにおいて血管形成、増殖および転移に関与する生理活性脂質です。アラキドン酸12-リポキシゲナ-ゼ(12-LOX)はアラキドン酸を12(S)-(HETE)に変換します。前立腺癌など種々のがんで12-LOXの発現および活性の変化が報告されています。
多くの腫瘍細胞株に発現する12-リポキシゲナ-ゼの経路を介したアラキドン酸の腫瘍誘導性代謝物です。冠動脈微小血管で産生され、これら微小血管の弛緩および過分極の強力な誘導因子として作用します。冠動脈微小血管平滑筋の大コンダクタンスCa2+活性化K+電流を活性化します。
Packaging
アルゴン封入しています。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
保管分類
3 - Flammable liquids
wgk
WGK 1
flash_point_f
55.4 °F
flash_point_c
13 °C
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Journal of diabetes investigation, 10(3), 639-649 (2018-09-27)
Diabetes is an important risk factor for atherosclerotic disease. The initiating factor of atherosclerosis is local endothelial cell injury. The arachidonic acid metabolite, 12(S)-hydroxyeicosatetraenoic acid (12[S]-HETE), might be involved in this process. In recent years, some studies have discussed the
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Cancer management and research, 11, 8303-8313 (2019-10-02)
To clarify the effect of 12-lipoxygenase/12-hydroxyeicosatetraeonic acid (12-LOX/12-HETE) on progress of esophageal squamous cell carcinoma (ESCC) and the possible mechanism. We performed cell experiments including chemical treatment, transfection, Western blotting and transwell assay to investigate the function of 12-LOX/12-HETE. Slices
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