H9411

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit

Name: Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

別名:

Anti-AHO3, Anti-BDMR, Anti-HA6116, Anti-HD4, Anti-HDAC-4, Anti-HDAC-A, Anti-HDACA

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この商品について

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03791601

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IF, IP, WB

Species reactivity:

rat, human, mouse

Citations:

Technique(s):

immunoprecipitation (IP): 10-20 μg using RIPA extract of HeLa nuclei, indirect immunofluorescence: 1:250 using HeLa cells, microarray: suitable, western blot: 1:1,000 using whole extracts of mouse NIH3T3 cells, western blot: 1:500 using whole extracts of rat brain

Uniprot accession no.:

P56524

主要文書

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~140 kDa (additional weaker bands may be present)

species reactivity

rat, human, mouse

enhanced validation

independent
Learn more about Antibody Enhanced Validation

technique(s)

UniProt accession no.

P56524

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HDAC4(9759)
mouse ... Hdac4(208727)
rat ... Hdac4(363287)

Application

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit has been used in:

immunoblotting
immunoprecipitation
immunofluorescence
immunostaining
immunohistochemistry
chromatin immunoprecipitation

Biochem/physiol Actions

Histone deacetylase 4 (HDAC4) exhibits intrinsic nuclear import and export signals for its dynamic nucleocytoplasmic shuttling. Its association with 14-3-3 and monocyte enhancer factor 2 (MEF2) proteins can disturb shuttling and thus directs HDAC4 to the cytoplasm and the nucleus, respectively.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Mammalian histone deacetylases (HDACs) can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins histone deacetylase 4,5,6,7,8,9, 10 (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10.

Immunogen

synthetic peptide corresponding to amino acid residues 1-19 of human HDAC4 with C-terminal added lysine conjugated to KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

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保管分類

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

H9411-VAR: + H9411-200UL: + H9411-BULK: + IXO11342:

jan

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試験成績書（COA）

Lot/Batch Number

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COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

Fischle W, et al.

Molecular Cell, 9(1), 45-57 (2002)

Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells.

Lilian Varricchio et al.

The international journal of biochemistry & cell biology, 50, 112-122 (2014-03-07)

To clarify the role of HDACs in erythropoiesis, expression, activity and function of class I (HDAC1, HDAC2, HDAC3) and class IIa (HDAC4, HDAC5) HDACs during in vitro maturation of human erythroblasts were compared. During erythroid maturation, expression of HDAC1, HDAC2

HDAC4 governs a transcriptional program essential for synaptic plasticity and memory

Sando III R, et al.

Cell, 151(4), 821-834 (2012)

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

Sailaja BS, et al.

Proceedings of the National Academy of Sciences of the USA, 109(52), E3687-E3695 (2012)

Histone deacetylase inhibitors preserve white matter structure and function during ischemia by conserving ATP and reducing excitotoxicity

Baltan S, et al.

The Journal of Neuroscience, 31(11), 3990-3999 (2011)

Anti-Histone Deacetylase 4 (HDAC4) (ML-19) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

サイズを選択してください

この商品について

主要文書

特性

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

enhanced validation

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

関連するカテゴリー

詳細

Application

Biochem/physiol Actions

Disclaimer

General description

Immunogen

Physical form

安全性情報

保管分類

wgk

flash_point_f

flash_point_c

適用法令

H9411-VAR: + H9411-200UL: + H9411-BULK: + IXO11342:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

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