I1395
IL-6 human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
別名:
hIL-6, IL-6
製品名
インターロイキン-6 ヒト, IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
0.2-2.0 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
26 kDa
packaging
pkg of 10 and 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... IL6(3569)
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関連するカテゴリー
Biochem/physiol Actions
インターロイキン-6（IL-6）は、二重鎖RNAで刺激された細胞の培養液中に見出された多機能性のタンパク質です。IL-6は、感染や損傷の後に起こる反応に直接関与していることが知られており、急性期反応の制御においてIL-1やTNF-αと同様に重要であることが証明されています。IL-6は、線維芽細胞、活性化T細胞、活性化単球またはマクロファージ、そして内皮細胞によって産生されることが報告されています。線維芽細胞、骨髄系前駆細胞、T細胞、B細胞、および肝細胞に作用します。IL-6は、その多数の同意語（形質細胞腫増殖因子（PCT-GF）、インターフェロンβ2（IFN-β2）、単球由来ヒトB細胞成長因子、B細胞刺激因子（BSF-2）、肝細胞刺激因子（HSF）、インターロイキンハイブリドーマ/形質細胞腫-1（IL-HP1））が示すように、複数の効果を誘導します。さらに、IL-6は、Tリンパ球の増殖においてIL-2と相互作用します。IL-6はまた、多分化造血前駆細胞におけるIL-3の増殖効果を増強します。
Physical form
凍結乾燥品(0.2 μmフィルター濾過済み、PBS溶液、pH 7.4、500 μg BSA含有)。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Maria Ferraiuolo et al.
Cancer letters, 433, 18-32 (2018-06-23)
Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are
Jee Eun Choi et al.
STAR protocols, 3(2), 101389-101389 (2022-05-24)
Metabolic reprogramming is associated with myeloid-derived suppressor cell (MDSC) immunosuppressive function. Here, we outline the process for acquiring MDSCs from human and murine sources for subsequent analysis of fatty acid oxidation, oxidative phosphorylation, and glycolysis using the Seahorse XFe 96
Adriana Catalli et al.
PloS one, 9(5), e96891-e96891 (2014-05-14)
Despite the fact that glucocorticoids and long acting beta agonists are effective treatments for asthma, their effects on human mast cells (MC) appear to be modest. Although MC are one of the major effector cells in the underlying inflammatory reactions
Bin Zhang et al.
Stem cells and development, 23(11), 1233-1244 (2013-12-26)
Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle, is immunologically active. MSC exosomes induced polymyxin-resistant, MYD88-dependent secreted embryonic alkaline phosphatase (SEAP) expression in a THP1-Xblue
Jahangir Abdi et al.
PloS one, 9(5), e96608-e96608 (2014-05-06)
In multiple myeloma (MM), the malignant plasma cells usually localize to the bone marrow where they develop drug resistance due to adhesion to stromal cells and various environmental signals. Hence, modulation of this interaction is expected to influence drug sensitivity
資料
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
関連コンテンツ
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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