I1645
インターロイキン-8 ヒト
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
別名:
IL-8
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この商品について
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
monomer 8.9 kDa ((77 aa))
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg (LAL test)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL8(3576)
Application
Interleukin-8 (IL-8) human has ben used to:
- measure neutrophil chemotoxis
- study the uptake of apoptotic cells by meningothelial cells
- study the effect of IL-8 on expression and secretion of urocortin-1 by human umbilical vein endothelial cells
Biochem/physiol Actions
インタ-ロイキン-8 (IL-8) は以前は単球由来好中球走化性因子と呼ばれ、ケモカインαまたはC-X-Cファミリ-に属します。成熟型IL-8には他のケモカインファミリ-と同様に4個のシステイン残基があり、最初の2つのシステイン残基はグルタミンにより隔てられています。ヒト成熟型IL-8は72残基からなり、分子量は8.4 kDaです。IL-8は、ミエロペルオキシダ-ゼ、 αマンノシダ-ゼ、βグルクロニダ-ゼなどの酵素測定において、in vitroでT細胞、好塩基球に対する遊走能を示します。IL-8は血管新生因子です。
Interleukin-8 (IL-8) was formerly called monocyte-derived neutrophil chemotactic factor. It belongs to the chemokine α or C-X-C family. Like other members of this family, the mature form of IL-8 has four cysteine residues and the first two cysteine residues are separated by glutamine. IL-8 shows chemotactic activity in vitro for T cells, neutrophils and basophils. Mutation in IL-8 can increase risk to acute pancreatitis.
Physical form
凍結乾燥品 (添加物不含, 0.2 μm濾過済み)。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
I1645-VAR: + I1645-BULK: + I1645-10UG-PW: + I1645-10UG:
jan
L M Nemec et al.
Journal of dairy science, 95(8), 4568-4577 (2012-07-24)
The aim of this study was to compare effects of inorganic sulfate versus chelated forms of supplemental Cu, Mn, and Zn on milk production, plasma and milk mineral concentrations, neutrophil activity, and antibody titer response to a model vaccination. Holstein
Lavínia E Borges et al.
Peptides, 74, 64-69 (2015-11-10)
Urocortin 1 (Ucn1) is a 40-amino-acid peptide that has vasodilatory activity and displays immunomodulatory and antioxidant properties. Maternal and cord plasma Ucn1 levels are increased in preeclampsia and preterm labor, but the mechanisms of such increase are poorly known. Thus
Ascentia M Seboko et al.
Frontiers in physiology, 9, 1812-1812 (2019-01-12)
It is known that advanced metabolic disorders such as type 2 diabetes compromise the functional and regenerative capacity of endogenous adipose-tissue resident stem cells (ADSCs). It is, however, still unclear at which stage of disease progression ADSCs become compromised and