I2764
ML-7
≥98% (TLC), myosin light chain kinase inhibitor, powder
別名:
1-(5-ヨードナフタレン-1-スルホニル)-1H-ヘキサヒドロ-1,4-ジアゼピン 塩酸塩
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この商品について
実験式（ヒル表記法）:
C15H17IN2O2S · HCl
CAS番号:
分子量:
452.74
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
製品名
ML-7, powder
SMILES string
Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
KDDALCDYHZIZMH-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
color
white
solubility
ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Gene Information
human ... MYLK(4638), MYLK2(85366)
Application
ML-7は、さまざまな実験でミオシン軽鎖キナーゼ（MLCK）阻害剤として使用されています。
Biochem/physiol Actions
ミオシン軽鎖キナ-ゼの選択的インヒビタ-です。
Features and Benefits
この化合物は、Handbook of Receptor Classification and Signal Transduction（受容体分類およびシグナル伝達ハンドブック）のCa/CaMKのページに記載されています。ハンドブックのその他のページをご覧になるには、こちらをクリックしてください。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Iwona Bil-Lula et al.
Frontiers in bioscience (Landmark edition), 23, 298-309 (2017-09-21)
Matrix metalloproteinase-2 (MMP-2) mediated degradation of myosin light chain 1 (MLC1) and troponin I (TnI) contributes to myocardial ischemia/reperfusion (I/R) injury. Modifications of MLC1 triggered by oxidative stress are mediated by myosin light chain kinase (MLCK), nitric oxide synthase (NOS)
Ziad Al Nabhani et al.
Inflammatory bowel diseases, 23(7), 1109-1119 (2017-05-19)
Crohn's disease (CD) pathogenesis is multifactorial involving genetic and environmental factors. Loss of function mutations in the nucleotide oligomerization domain 2 (NOD2) gene are the main genetic risk factor for CD. Like patients with CD, Nod2 mice are characterized by
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
Jing Du et al.
Cell systems, 9(2), 214-220 (2019-07-08)
Mechanical factors play critical roles in mammalian development. Here, we report that colony-growing mouse embryonic stem cells (mESCs) generate significant tension on the colony surface through the contraction of a three-dimensional supracellular actomyosin cortex (3D-SAC). Disruption of the 3D-SAC, whose
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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