IL-1β mouse

Interleukin-1β (IL-1β) cytokine is generated by monocytes, dendritic cells, macrophages and keratinocytes. Pro-IL-1β, an IL-1β precursor undergoes proteolytic cleavage to produce its active form of 17 kDa.

Interleukin-1β from mouse has been used:

• as a proinflammatory agent, to induce inflammatory signaling cascades mediated cellular damage
• to study its effect on fetuin A-induced inflammatory response in podocyte
• to check its effect on the expression of mitogen-activated protein kinase 4 using 3T3-L1 adipocytes

Interleukin-1β (IL-1β) is a potent inflammatory cytokine, and mediates inflammation through proinflammatory molecules: cyclooxygenase-2 (COX2) and nitric oxide. IL-1β release is stimulated by injury and increased levels are observed in response to severe pain. It has its main function in T-cell activation, antigen recognition and T-helper cell 17 cell development. IL-1β is also responsible for the formation of IL-17 and IL-22 by nature killer T (NKT) cells and NK cells. It is known to induce inflammation in psoriasis and rheumatoid arthritis. IL-1β controls intercellular adhesion molecule-1 expression. It is significantly associated with bone damage and vascular injury.

凍結乾燥品(0.2 μmフィルターで滅菌濾過済み、10 mMクエン酸ナトリウム、pH 4.0を含有)。

生物活性は、マウスD10S細胞の用量依存性刺激を指標として測定しました。

インターロイキン1α(IL-1α)とインターロイキン1B(IL-1Β)という2つの密接に関連する物質は、同じ細胞表面受容体に結合し、ほぼ同一の生物学的反応を誘発しますが、アミノ酸配列の相同性は25%です。