I5281
L-イソロイシン
別名:
(2S, 3S)-2-アミノ-3-メチルペンタン酸
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この商品について
化学式:
C2H5CH(CH3)CH(NH2)CO2H
CAS番号:
分子量:
131.17
UNSPSC Code:
12352209
NACRES:
NA.26
eCl@ss:
32160406
EC Number:
200-798-2
Beilstein/REAXYS Number:
1721792
MDL number:
InChI
1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1
InChI key
AGPKZVBTJJNPAG-WHFBIAKZSA-N
SMILES string
CC[C@H](C)[C@H](N)C(O)=O
biological source
non-animal source
assay
≥98.5%
form
crystalline powder
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, heavy metals, residual solvents, tested
mp
288 °C (dec.) (lit.)
solubility
1 M HCl: 50 mg/mL
application(s)
pharmaceutical (small molecule)
foreign activity
cytotoxicity, tested
Quality Level
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関連するカテゴリー
Application
L-Isoleucine is an essential amino acid. It can be biosynthesized from threonine or through fermentation of carbohydrates. The amino acid L-isoleucine is an isomer of L-Leucine, differing in the position of the side chain. It is also considered to be a branched chain amino acid, along with L-Leucine and L-Valine, which are sources of fuel and/or transport during cell development. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
General description
Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
M-Clarity Program
Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Eva Blomstrand et al.
The Journal of nutrition, 136(1 Suppl), 269S-273S (2005-12-21)
BCAAs (leucine, isoleucine, and valine), particularly leucine, have anabolic effects on protein metabolism by increasing the rate of protein synthesis and decreasing the rate of protein degradation in resting human muscle. Also, during recovery from endurance exercise, BCAAs were found
L Edvinsson
Blood vessels, 28(1-3), 35-45 (1991-01-01)
The cerebral circulation is supplied with two vasodilator systems: the parasympathetic system storing vasoactive intestinal peptide, peptide histidine isoleucine, acetylcholine and in a subpopulation of nerves neuropeptide Y, and the sensory system, mainly originating in the trigeminal ganglion, storing substance
Urho M Kujala et al.
Circulation, 127(3), 340-348 (2012-12-22)
Long-term physical inactivity seems to cause many health problems. We studied whether persistent physical activity compared with inactivity has a global effect on serum metabolome toward reduced cardiometabolic disease risk. Sixteen same-sex twin pairs (mean age, 60 years) were selected
Toshihiro Sato et al.
The Journal of biological chemistry, 278(6), 4314-4321 (2002-11-22)
Previously, we determined the crystal structures of the dimeric ligand binding region of the metabotropic glutamate receptor subtype 1. Each protomer binds l-glutamate within the crevice between the LB1 and LB2 domains. We proposed that the two different conformations of
Anna L Vestergaard et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), E1334-E1343 (2014-04-08)
P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has remained an enigma. We have investigated the
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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