L2761

[des-Gly¹⁰, D-His(Bzl)⁶]-LH-RHエチルアミド

Name: [des-Gly<SUP>10</SUP>, <SC>D</SC>-His(Bzl)<SUP>6</SUP>]-LH-RHエチルアミド
Brand: SIGMA

≥97% (HPLC), powder

別名:

ヒストレリン

ログインで組織・契約価格をご覧ください。

サイズを選択してください

この商品について

実験式（ヒル表記法）:

C₆₆H₈₆N₁₈O₁₂

CAS番号:

76712-82-8

分子量:

1323.50

NACRES:

NA.32

PubChem Substance ID:

24896325

UNSPSC Code:

12352209

MDL number:

MFCD00133494

主要文書

すべての文書を表示

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

テクニカルサービス

お困りのことがあれば、経験豊富なテクニカルサービスチームがお客様をサポートします。

お手伝いします

InChI

1S/C66H86N18O12/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71)

SMILES string

CCNC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc2cn(Cc3ccccc3)cn2)NC(=O)C(Cc4ccc(O)cc4)NC(=O)C(CO)NC(=O)C(Cc5c[nH]c6ccccc56)NC(=O)C(Cc7cnc[nH]7)NC(=O)C8CCC(=O)N8

InChI key

HHXHVIJIIXKSOE-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ~70%

UniProt accession no.

P55248, P01148, P07490, P13562, P30968, P30969, Q01776

storage temp.

−20°C

Quality Level

200

Gene Information

human ... GNRH1(2796), GNRHR(2798)
mouse ... GNRH1(14714), GNRHR(14715)
rat ... GNRH1(25194), GNRHR(81668)

Application

[des-Gly¹⁰, D-His(Bzl)⁶]-LH-RH ethylamide has been used:

for inducing Batrachoseps gravid females to oviposit
for comparing the effect of LHRH (luteinizing hormone-releasing hormone) agonists and dopamine antagonists in Lithobates pipiens
for inducing oviposition in females of Taricha granulosa and Ensatina eschscoltzii
to induce spawning in Spea hammondii adults

Biochem/physiol Actions

Glp-His-Trp-Ser-Tyr-His(Bzl)-Leu-Arg-Pro-NHEt ([des-Gly¹⁰, D-His(Bzl)⁶]-LH-RH) is a GnRH (gonadotropin-releasing hormone) agonist, histerelin. GnRH (Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2), which is also referred as LHRH (luteinizing hormone-releasing hormone) or gonadorelin, is crucial for mammalian reproduction and is released from hypothalamic neurons. It is responsible for the secretion of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the pituitary glands. Mutations in GnRH are associated with normosmic congenital hypogonadotropic hypogonadism. Histerelin is used for the treatment of central precocious puberty in children. It inhibits actions of sex steroids on the male and female reproductive organs.

Features and Benefits

その他のLH-RHアゴニストと比較して脂溶性が高いにもかかわらず、水に対する溶解性も保持しています。

pictograms

GHS08

signalword

Danger

hcodes

H360

pcodes

P201 - P308 + P313

Hazard Classifications

Repr. 1B

保管分類

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

L2761-.1MG: + L2761-BULK: + L2761-.5MG-PW: + L2761-PH: + L2761-.5MG: + L2761PROC: + L2761-1MG-PW: + L2761-VAR: + L2761-BULK-N: + L2761-PPG: + L2761-1MG:

jan

最新バージョンのいずれかを選択してください：

試験成績書（COA）

Lot/Batch Number

適切なバージョンが見つかりませんか。

特定のバージョンが必要な場合は、ロット番号またはバッチ番号で特定の証明書を検索できます。

COAを検索

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Inhibition of the action of sex steroids by gonadotropin-releasing hormone (GnRH) agonists: a new biological effect.

K Sundaram et al.

Life sciences, 28(1), 83-88 (1981-01-05)

Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience.

K O Klein et al.

The Journal of clinical endocrinology and metabolism, 86(10), 4711-4716 (2001-10-16)

We report 98 children who have reached final adult height in a long-term trial of LHRH agonist treatment. These children were 5.3 +/- 2.1 yr old at the start of treatment and were treated with either deslorelin (4 microg/kg.d sc)

Relationships between FSH, inhibin B, anti-Mullerian hormone, and testosterone during long-term treatment with the GnRH-agonist histrelin in patients with prostate cancer.

Talia Eldar-Geva et al.

European journal of endocrinology, 162(1), 177-181 (2009-10-13)

Medical castration with long-acting GnRH-agonist (GnRHa) is a well-established treatment for metastatic prostate cancer. Our aim was to explore the relationships between FSH, inhibin B, anti-Mullerian hormone (AMH), and testosterone during treatment with an implant releasing GnRHa. Analysis of hormone

Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty.

Martina Weise et al.

The Journal of clinical endocrinology and metabolism, 89(1), 103-107 (2004-01-13)

In children with precocious puberty (PP), treatment with GnRH analogs (GnRHa) often decreases height velocity below normal. Based on previous animal studies, we hypothesized that this impaired growth is due to excessive advancement in growth plate senescence induced by the

Random luteinizing hormone often remains pubertal in children treated with the histrelin implant for central precocious puberty.

Katherine A Lewis et al.

The Journal of pediatrics, 162(3), 562-565 (2012-10-09)

To investigate the use of random ultrasensitive (US) luteinizing hormone (LH) levels to monitor children being treated with a histrelin implant for central precocious puberty (CPP). This was a prospective, uncontrolled, observational study at a pediatric endocrinology tertiary center. Thirty-three

[des-Gly¹⁰, D-His(Bzl)⁶]-LH-RHエチルアミド

≥97% (HPLC), powder

サイズを選択してください

この商品について

主要文書

特性

InChI

SMILES string

InChI key

assay

form

composition

UniProt accession no.

storage temp.

Quality Level

Gene Information

詳細

Application

Biochem/physiol Actions

Features and Benefits

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

L2761-.1MG: + L2761-BULK: + L2761-.5MG-PW: + L2761-PH: + L2761-.5MG: + L2761PROC: + L2761-1MG-PW: + L2761-VAR: + L2761-BULK-N: + L2761-PPG: + L2761-1MG:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

テクニカルサービス

[des-Gly10, D-His(Bzl)6]-LH-RHエチルアミド

≥97% (HPLC), powder

サイズを選択してください

この商品について

主要文書

特性

InChI

SMILES string

InChI key

assay

form

composition

UniProt accession no.

storage temp.

Quality Level

Gene Information

詳細

Application

Biochem/physiol Actions

Features and Benefits

安全性情報

pictograms

signalword

hcodes

pcodes

Hazard Classifications

保管分類

wgk

flash_point_f

flash_point_c

ppe

適用法令

L2761-.1MG: + L2761-BULK: + L2761-.5MG-PW: + L2761-PH: + L2761-.5MG: + L2761PROC: + L2761-1MG-PW: + L2761-VAR: + L2761-BULK-N: + L2761-PPG: + L2761-1MG:

資料

試験成績書（COA）

以前この製品を購入いただいたことがある場合

参考文献

テクニカルサービス

[des-Gly¹⁰, D-His(Bzl)⁶]-LH-RHエチルアミド