L5163
ラトランクリンA
From sea sponge, ≥85% (HPLC), Inhibitor of actin assembly and polymerization, waxy solid
別名:
LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-ヒドロキシ-5,12-ジメチル-3-オキソ-2,16-ジオキサビシクロ[13.3.1]ノナデカ-4,8,10-トリエン-17-イル)-2-チアゾリジノン
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この商品について
実験式（ヒル表記法）:
C22H31NO5S
CAS番号:
分子量:
421.55
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
製品名
ラトランクリンA, from sea sponge, ≥85% (HPLC), waxy solid
SMILES string
C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1
InChI
1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
InChI key
DDVBPZROPPMBLW-IZGXTMSKSA-N
biological source
sea sponge
assay
≥85% (HPLC)
form
waxy solid
mol wt
421.6
solubility
DMSO: soluble
ethanol: soluble
storage temp.
−20°C
Quality Level
Application
ラトランクリンAは、A549ヒト肺癌細胞におけるCAV9の内部移行のメカニズムを判定するためのA549細胞培地サプリメントとして使用されています。
Biochem/physiol Actions
ラトランクリンAは、サイトカラシンとは異なるメカニズムでアクチン重合を阻害します。ラトランクリンAは、微小フィラメントを介したプロセスを阻害します。
General description
赤色の海綿（Latrunculia magnifica）から抽出した毒素である、ラトランクリンA。本化合物は、in vitroで純正アクチンの重合の形態学的変化に関与します。アクチンフィラメント伸長のため、ヌクレオチドのクレフトと結合し複合体を形成します。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
E G Yarmola et al.
The Journal of biological chemistry, 275(36), 28120-28127 (2000-06-22)
Latrunculin A is used extensively as an agent to sequester monomeric actin in living cells. We hypothesize that additional activities of latrunculin A may be important for its biological activity. Our data are consistent with the formation of a 1:1
Peter J Wen et al.
Nature communications, 7, 12604-12604 (2016-09-01)
Vesicle fusion is executed via formation of an Ω-shaped structure (Ω-profile), followed by closure (kiss-and-run) or merging of the Ω-profile into the plasma membrane (full fusion). Although Ω-profile closure limits release but recycles vesicles economically, Ω-profile merging facilitates release but
Zhanghan Wu et al.
Nature communications, 9(1), 136-136 (2018-01-13)
Immune cells exhibit stimulation-dependent traveling waves in the cortex, much faster than typical cortical actin waves. These waves reflect rhythmic assembly of both actin machinery and peripheral membrane proteins such as F-BAR domain-containing proteins. Combining theory and experiments, we develop
Keiichiro Kushiro et al.
Scientific reports, 7(1), 4244-4244 (2017-06-28)
During metastasis, cancer cells are exposed to various three-dimensional microstructures within the body, but the relationship between cancer migration and three-dimensional geometry remain largely unclear. Here, such geometric effects on cancerous cells were investigated by characterizing the motility of various
Maureen Möckel et al.
Journal of virology, 93(16) (2019-05-31)
Dynamin GTPases, best known for their role in membrane fission of endocytic vesicles, provide a target for viruses to be exploited during endocytic uptake. Recently, we found that entry of herpes simplex virus 1 (HSV-1) into skin cells depends on
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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